Vascular Effects of a Single Bout of Electronic Cigarette Use
Phase 1
Completed
- Conditions
- Arterial Stiffness
- Interventions
- Registration Number
- NCT03209661
- Lead Sponsor
- University of Texas at Austin
- Brief Summary
Investigating the acute effects of a single use E-Cigarette upon vascular health.
- Detailed Description
Subjects will inhale e-cigarettes of 5.4%, 0%, and sham menthol inhaler to determine the effects upon to measures of vascular health. These measures will include Cardio-Ankle Vascular Index and Flow Mediated Dilation.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
Inclusion Criteria
- Apparently healthy, with no cardiovascular or metabolic diseases. Additionally, is not a frequent smoker of any kind.
Exclusion Criteria
- Cardiovascular or Metabolic Diseases and/or regular smoker.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description E-Cigarette 0% NBV Nicotine 0% Subjects will be asked to inhale an E-Cigarette with 0% NBV for 6 min. E-Cigarette 5.4% NBV E-cigarette Subjects will be asked to inhale an E-Cigarette with 5.4% NBV for 6 min. Menthol Inhaler Menthol Inhalant Product Subjects will be asked to inhale a sham methole inhaler (that looks identical in looks to E-cigarette) for 6 minutes. This arm is to control for a potential effect of menthole.
- Primary Outcome Measures
Name Time Method Changes in arterial stiffness and endothelial function with e-cigarette use. Immediately Post, 1 hour, and 2 hour. Arterial stiffness and endothelial function are two of the subclinical markers of vascular dysfunction
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Cardiovascular Aging Research Lab at UT Austin
🇺🇸Austin, Texas, United States