Autologous Serum Skin Test and Serum IL-18 Levels in Chronic Idiopathic Urticaria and Respiratory Allergic Diseases

Completed

• Conditions: Urticaria; Respiratory Allergic Diseases
• Interventions: Procedure: autologous serum skin test, serum IL-18

• Registration Number: NCT01091402
• Lead Sponsor: Eskisehir Osmangazi University

Brief Summary

One of the proposed mechanisms in CU is autoimmunity. It was shown by a positive response to autologous serum skin test (ASST)in almost half of chronic urticaria (CU) patients. IL-18 also play a role in autoimmune disorders. The investigators aim was to investigate the relationship of ASST and IL-18 in CU and respiratory allergic diseases.

Detailed Description

Not available

Study Timeline

• Status Verified: 2009-01
• Study Start: 2009-01
• Study First Submitted: 2010-03-23
• Study First Submitted QC: 2010-03-23
• Last Update Submitted: 2010-03-23
• Study First Posted: 2010-03-24
• Last Update Posted: 2010-03-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• adult patients
• chronic urticaria patients
• stable asthma patients
• allergic rhinitis patients with sensitized to pollens
• normal controls without atopic and skin disease.

Exclusion Criteria

• unwillingness to the study
• other dermatological problems that could affect the skin test
• use of antihistamine drugs

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
seasonal allergic rhinitis	autologous serum skin test, serum IL-18	-
normal controls	autologous serum skin test, serum IL-18	-
asthma	autologous serum skin test, serum IL-18	-
chronic urticaria	autologous serum skin test, serum IL-18	-

Trial Locations

Locations (1)

Eskisehir Osmangazi University; 🇹🇷 Eskisehir, Turkey