Association of Maternal and Neonatal Umbilical Cord Blood Levels of Propofol Administered for Induction of General Anesthesia With Perinatal Findings in Gravidas Undergoing Cesarean Section
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- Blood propofol concentration
研究概览
简要总结
The effects of intravenous propofol administration for general anesthesia in cesarean deliveries on maternal and infant health will be evaluated in relation to maternal and umbilical cord blood propofol levels.
详细描述
After the ethics committee approval was obtained, volunteers who met the criteria for inclusion in the study were included in the study after obtaining their written permission. After the patients were taken to the operating room, IV catheterization was achieved after CTA, TA and sPO2 monitoring, and the patient was intubated 2 minutes after induction of propfol at 3 mg/kg and rocuronium at 0.6 mg/kg. After the baby was born, an intravenous blood sample was taken from the umbilical cord and the mother simultaneously. After the venous blood samples were obtained as 3 μL, the serum samples obtained by centrifugation as standard were portioned in equal volume to 500 μL Eppendorf tubes and stored at -80°C. After this pre-treatment, propofol was subjected to measurement tests with HPLC, and the collected data were added
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Being pregnant in ASA category 1-2
- •>39 weeks of healthy pregnancy
- •>28 weeks complicated pregnancy
- •Cesarean delivery with or without action
- •Providing induction of general anesthesia with intravenous propofol
排除标准
- •Pregnant women under the age of 18,
- •Those who have stillbirth,
- •Severe chronic kidney and liver disease,
- •Neurological disease
- •Those with other systemic diseases
研究组 & 干预措施
Women with Healthy Pregnance undergone Caesarean Section
Healthy Pregnant Women between the ages of 18 and 40
干预措施: Caesarean Section (Drug)
Women Compliceted Pregnance undergone Caesarean Section
Pregnant women between the ages of 18-40 with Pearclampsia, Preterm Labor, Fetal Growth Retardation, Gestational Diabetes
干预措施: Caesarean Section (Drug)
结局指标
主要结局
Blood propofol concentration
时间窗: The first 5 minutes of cesarean delivery
ng/ml
次要结局
未报告次要终点
研究者
Emine Yilmaz Guler
Obstetric Anesthesia Specialist
Haseki Training and Research Hospital
