ACTRN12622001074785招募中未知
The effect of positive airway pressure therapy on cardiac remodeling, cardiovascular risk factors and neurocognitive function in patients with chronic obstructive pulmonary disease and obstructive sleep apnoea overlap syndrome.
适应症
试验速览
- 阶段
- 未知
- 状态
- 招募中
- 入组人数
- 20
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 40 Years 至 o limit（—）
- 性别
- All
入选标准
- •Participants must be aged 40 years old or older.
- •At least 10 pack-year smoking history.
- •Spirometry demonstrating post bronchodilator FEV1/FVC less than the lower limits of normal (LLN) and FEV1 less than the LLN.
- •Polysomnography (PSG) or level 2 home sleep study performed within the last 6 months of first medical visit demonstrating apnoea hypopnoea index (AHI) of equal to or greater than 30.
- •Patient is not already on PAP therapy and the treating physician deems patient should start PAP therapy.
排除标准
- •Unstable patients (COPD exacerbation within last 4 weeks or myocardial infarction or stroke within the last 6 weeks)
- •Neuromuscular disease.
- •Sleep disorders other than OSA.
- •Patients who have a contraindication to or don’t tolerate CMRI or PAP therapy.
- •Moderate or greater valvular heart disease.
- •Renal insufficiency with eGFR<30 ml/min/1.73m2
- •Unstable Malignancy.
- •History of major psychiatric disorder in the last 12 months which is likely to affect adherence to trial protocol and follow up
- •Willingness to provide informed consent and willingness to participate and comply with the study requirements.
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