Evaluation of the effect of the treatment with airway positive pressure device on blood pressure levels of hypertensive patients with sleep apnea syndrome.
Not Applicable
Recruiting
- Conditions
- Resistant Hypertension, Obstructive Sleep Apnea SyndromeC08.618.085.852.850G47.3C14.907.489
- Registration Number
- RBR-6mbrrk
- Lead Sponsor
- Faculdade de Medicina - Universidade Federal do Rio de Janeiro
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- recruiting
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Patients with resistant hypertension and moderate-severe obstructive sleep apnea syndrome
Exclusion Criteria
Marked cognitive deficit, non-adherence to anti-hypertensive treatment
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinic and ambulatory blood pressures.<br>Measure: clinic and ambulatory blood pressure monitoring<br>Expected outcome: reduction of blood pressures in treatment group (at least 5 mmHg).
- Secondary Outcome Measures
Name Time Method Microalbuminuria.<br>Measure: 24-hour urinary albumin excretion.<br>Expected outcome: reduction of microalbuminuria in the intervention group.;Hyperaldosteronism measurements: serum aldosterone concentration, plasma renin activity and 24-hour urinary aldosterone excretion.<br>Expected outcome: reduction of hyperaldosteronism in the intervention group.<br>;Aortic arterial stiffness.<br>Measure: carotid-femoral pulse wave velocity.<br>Expected outcome: reduction of arterial stiffness in the intervention group.;Cardiorespiratory fitness.<br>Measure: maximun oxigen consumption in ergospirometry.<br>Expected outcome: improvement in cardiorespiratory fitness in the intervention group.;Autonomic System Balance Measurements: heart rate variability during 24-hour Holter monitoring.<br>Expected outcome: improvement in heart rate variability in the intervention group.