ACTRN12614001202651
Completed
N/A
Can continuous positive airway pressure treatment of patients with moderate obstructive sleep apnoea prevent sleep apnoea-related brain damage?
Dr. Carrie Innes0 sites45 target enrollmentNovember 17, 2014
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Moderate obstructive sleep apnoea (between 15 and 29 hypopnoea or apnoea events per hour during sleep).
- Sponsor
- Dr. Carrie Innes
- Enrollment
- 45
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •All participants:
- •Be at least 18 yrs but no older than 80 yrs.
- •Normal time to bed between the hours of 0900 pm and 1200 am.
- •Normal time in bed of 7 to 9 hours.
- •Have a basic ability in English (verbal and written).
- •Participants with moderate OSA:
- •Be diagnosed with moderate OSA (15 \- 29 OSA\-related events per hour during Level 2 Sleep Study.
- •Participants without OSA:
- •Have \<10 OSA\-related events per hour during Level 2 Sleep Study.
Exclusion Criteria
- •Currently receiving or previously received OSA treatment.
- •A history of physiological, psychiatric, or neurological disorders that could affect or is affecting sleep behaviour, fatigue, cerebral perfusion or brain structure (e.g. chronic obstructive pulmonary disease, congestive heart disease, diabetes, heart failure, hypertension \> 150/90, migraine, myocardial infarction, stroke, previous brain surgery, stroke, traumatic brain injury, etc., but not mild depression).
- •Currently taking any medication that could impact on cerebral perfusion (e.g., ACE inhibitors, nitrates …).
- •Not willing or unable to give consent.
- •Not willing or unable to remove metal that could either be harmful to the participant during a MRI or could likely create MRI artefacts that negatively affect the quality of the scan.
- •Based on current Sleep Unit criteria, not have any reason for urgent treatment.
Outcomes
Primary Outcomes
Not specified
Similar Trials
Completed
N/A
CPAP treatment in stroke patients with OSADiseases of the nervous systemKCT0003688Chungnam National University Hospital80
Terminated
N/A
Treatment of Obstructive Sleep Apnoea for Cognitive Decline in Mild Cognitive ImpairmentACTRN12614000442606niversity of Sydney29
Completed
N/A
Continuous positive airway pressure therapy withdrawal - a model to evaluate treatment modalities for sleep apnoeaObstructive sleep apnoeaNervous System DiseasesSleep disordersISRCTN93153804niversity Hospital of Zurich (Switzerland)40
Completed
N/A
Treatment by uninterrupted positive airway pressure by nasal route - Evaluation of REMstar® Auto with C-Flex in clinical practiceSleep apnoea/ hypopnoea syndromeNervous System DiseasesSleep disordersISRCTN59353477Respironics International (France)20
Recruiting
N/A
A prospective observational study assessing the impact of positive airway pressure therapy in patients with chronic obstructive pulmonary disease and obstructive sleep apnoea (overlap syndrome).Chronic obstructive pulmonary diseaseObstructive sleep apnoeaCardiac remodelingCardiovascular diseaseCognitive impairmentRespiratory - Chronic obstructive pulmonary diseaseRespiratory - Sleep apnoeaCardiovascular - Other cardiovascular diseasesNeurological - Other neurological disordersACTRN12622001074785The University of Sydney20