TIPTOE - Investigating Peripheral T cell Tolerance in Colorectal Cancer

Not Applicable

Recruiting

• Conditions: Colorectal Cancer; Cancer - Bowel - Back passage (rectum) or large bowel (colon)

• Registration Number: ACTRN12622001037796
• Lead Sponsor: Peter MacCallum Cancer Centre

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-07-25
• Last Update Posted: 12 September 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

1. Subjects must have voluntarily provided written informed consent for the study.
2. Subjects must be at least 18 years of age at the time of consent.
3. Subject must have histologically confirmed or suspected colorectal adenocarcinoma.
4. Subjects must have stage IV disease based on the AJCC Cancer Staging Manual 8th edition.
5. Subjects must be undergoing surgical resection of their primary tumour at the Peter
MacCallum Cancer Centre as part of their routine oncological care.

Exclusion Criteria

1. Subjects unable to voluntarily provide written informed consent.
2. Subjects with stage I-III colorectal cancer.
3. Any medical or psychosocial reason that in the opinion of the investigator would make
the subject inappropriate for the study.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identification of a lymph node restricted CD8+ T cell population with a gene expression profile consistent with peripheral tolerance using single cell RNA sequence (scRNAseq) analysis of all obtained samples.[At completion of scRNAseq analysis of all obtained samples]