De effecten van een rechter paravertebraal blok op de werking van het hart bij patiënten met pulmonale hypertentie die minimaal invasieve mitralisklepchirugie ondergaan.

Conditions: patients with pulmonary hypertension scheduled for elective minimally invasive mitral valve surgery using heartport technique.
Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]

Registration Number: EUCTR2013-002000-14-BE

Lead Sponsor: niversity Hospitals Leuven

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Authorised-recruitment may be ongoing or finished

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

- patient scheduled for minimal invasive mitral valve surgery via right thoracotomy
- ASA II - IV
- chronic pulmonary hypertensio (systolic PAP >50 mmHg)
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 10
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range 40

Exclusion Criteria

- previous cardiac surgery
-contra-indication for TEE
- contra-indication for paravertebral block (allergies to local anesthetics, local infection, coagulation disorder, systemic inflammation,...)
- Tricupid insufficiency > 1/4
- patient refusal

Study & Design

Study Type: Interventional clinical trial of medicinal product

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: a right paravertebral block does not influence the baseline myocardial performance of both the right and left ventricle in patients with chronically increase right ventricular afterload.;Secondary Objective: A right paravertebral block inhibits the positive inotropic response of the right ventricular to an acute increase in right ventricular afterload;Primary end point(s): Right ventricular function;Timepoint(s) of evaluation of this end point: after insertion of the paravertebral catheter<br>after onset of unilateral sympathetic blockade<br>after 20 min of single lung ventilation

Secondary Outcome Measures