Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

Not Applicable

Recruiting

• Conditions: Traumatic Brain Injury; Attention Deficit Hyperactivity Disorder; Bipolar Disorder; Schizophrenia; Borderline Personality Disorder; Substance Use Disorders; Major Depressive Disorder

• Registration Number: NCT04296604
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain.

Detailed Description

In the current study, the investigators aim to understand the role of transcranial direct current stimulation (tDCS) in improving executive function across neuropsychiatric populations known to have deficits in this cognitive domain. The investigators will select 8 relevant diagnostic categories: traumatic brain injury, major depressive disorder, bipolar disorder, schizophrenia, attention deficit hyperactivity disorder, borderline personality disorder and substance use disorder. The study will also include a cohort of healthy controls for comparison.

Study Timeline

• Study Start: 2014-09
• Study First Submitted: 2020-02-28
• Study First Submitted QC: 2020-03-04
• Study First Posted: 2020-03-05
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-20
• Last Update Posted: 2024-03-22
• Primary Completion: 2024-09
• Study Completion: 2024-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in N-Back Task	Baseline to Post-Treatment, 1 Week	Working Memory Task

Secondary Outcome Measures

Name	Time	Method
Change in Delayed Discounting Task	Baseline to Post-Treatment, 1 Week	Decision-Making Task
Change in Stop Signal Task	Baseline to Post-Treatment, 1 Week	Ability to Inhibit a Response Task
Change in Iowa Gambling Task	Baseline to Post-Treatment, 1 Week	Risk-Taking Task
Change in Flanker Task	Baseline to Post-Treatment, 1 Week	Attention and Inhibitory Control Task
Change in Multi-Source Interference with International Affective Picture System Task	Baseline to Post-Treatment, 1 Week	Cognitive Control During Emotional Regulation Task

Trial Locations

Locations (1)

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States