Butorphanol and nalbuphine for tracheal intubatio
Phase 4
- Conditions
- Health Condition 1: K353- Acute appendicitis with localizedperitonitisHealth Condition 2: H721- Attic perforation of tympanic membraneHealth Condition 3: K800- Calculus of gallbladder with acutecholecystitisHealth Condition 4: H662- Chronic atticoantral suppurative otitis media
- Registration Number
- CTRI/2019/11/021949
- Lead Sponsor
- niversity College of MEdical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Sixty patients
ASA I or II
Modified Mallampati class I and II airway
scheduled for elective surgery under general anaesthesia requiring tracheal intubation will be included.
Exclusion Criteria
Non-consenting patients
History of allergy to opioids or sleep apnea
History of cardiovascular, cerebral, renal, hepatic, bronchospastic or endocrine disease or psychiatric disorder.
On anti-hypertensives, hypnotic or narcotic analgesics
Full stomach patients, pregnant and lactating females.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effect on heart rate (HR) and systolic blood pressure (SBP)Timepoint: T0 (baseline) <br/ ><br>T1 (After test drug administration) <br/ ><br>T2(before induction) <br/ ><br>T3(immediately before laryngoscopy) <br/ ><br>T4(after tracheal intubation) <br/ ><br>T5 (1 min) <br/ ><br>T6(3min) <br/ ><br>T7(5min) <br/ ><br>T8(10 min) <br/ ><br>T9(15min) <br/ ><br>
- Secondary Outcome Measures
Name Time Method Effect on diastolic blood pressure (DBP) and mean arterial pressure (MAP) <br/ ><br>Effect on rate pressure product (RPP) <br/ ><br>Effect on post-operative sedation <br/ ><br>The side effects <br/ ><br>Timepoint: T0 (baseline) <br/ ><br>T1 (After test drug administration) <br/ ><br>T2(before induction) <br/ ><br>T3(immediately before laryngoscopy) <br/ ><br>T4(after tracheal intubation) <br/ ><br>T5 (1 min) <br/ ><br>T6(3min) <br/ ><br>T7(5min) <br/ ><br>T8(10 min) <br/ ><br>T9(15min) <br/ ><br>