The neurochemical basis of goal-directed behavior

Withdrawn

• Conditions: psychiatrische en neurologische stoornissen; Psychiatric or neurological disorders such as schizophrenia and depression

• Registration Number: NL-OMON46785
• Lead Sponsor: niversiteit Leiden

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Age 18-30 years
Right-handed

Exclusion Criteria

- History of psychoactive medication (e.g., antidepressants, antipsychotics, amphetamines)
- History of substance (ab)use (e.g., smoking, cannabis, XTC)
- History of psychiatric/neurological disorders (e.g., depression, epilepsy, ADHD)
- Eating or using caffeinated drinks during the period of six hours prior to any of the sessions
- Heart-related disorders
- Metal objects in or around the body.
- Participation in a scientific examination where radiation was used, in the last year
- Positive urine drug screen on the day of the PET/CT scan. Participants will be tested on cannabis, amphetamine, XTC, cocaine and opiates.
- In women: positive pregnancy test on the day of the PET/CT scan and lactation.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameters are the regional [18F]DOPA influx (Ki) values,<br /><br>performance on computer tasks (typically accuracy and reaction time),<br /><br>psychophysiological measurements of for example blink rate and pupil dilation,<br /><br>self-reports using questionnaires, and structural & functional MRI.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>See primary study parameters</p><br>