Sickle Cell Children's Exercise Study (SuCCESs)

Not Applicable

Recruiting

• Conditions: Sickle Cell Disease

• Registration Number: NCT06074198
• Lead Sponsor: University of Maryland, Baltimore

Brief Summary

The Sickle Cell Children's Exercise Study (SuCCESs) will explore the feasibility and effects of a moderate intensity strengthening, balance, speed, and agility intervention program in children with sickle cell disease.

Detailed Description

Participants will perform the baseline assessment and after six weeks of performing the SuCCESs program the participants will perform a post-intervention assessment. Participants will be asked to attend a total of six physical therapy in-person sessions (1x/week) at the University of Maryland Department of Physical Therapy and Rehabilitation Science and to perform 12 home program sessions.

Study Timeline

• Study First Submitted: 2023-09-28
• Study First Submitted QC: 2023-10-05
• Study First Posted: 2023-10-10
• Study Start: 2023-11-03
• Status Verified: 2024-12
• Last Update Submitted: 2024-12-10
• Last Update Posted: 2024-12-16
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Children 6-17 years of age diagnosed with sickle cell disease

Exclusion Criteria

• Diagnosis of neurological disorder, not related to sickle cell disease
• Lower extremity injury such as a fracture with a cast

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
knee extension strength	week 1 and week 7	dynamometry to measure knee extension strength
Rate of Muscle Activation	week 1 and week 7	Electromyography used to measure rate of muscle activation
exercise tolerance	week 1 and week 7	6-Minute Walk Test used to measure exercise tolerance
locomotor efficiency	week 1 and week 7	oxygen uptake used to measure locomotor efficiency
number of sessions attended	throughout the entire study week 1, weeks 2-6, six weeks of intervention, and week 7	attendance

Trial Locations

Locations (2)

University of Maryland School of Medicine Dept. of Physical Therapy & Rehabilitation Science; 🇺🇸 Baltimore, Maryland, United States

University of Maryland, Baltimore; 🇺🇸 Baltimore, Maryland, United States