Enhanced Population-based Core Surveillance of Meningococcal Invasive Infections at Participating Centers Across Canada

• Conditions: Invasive Meningococcal Disease

• Registration Number: NCT04184336
• Lead Sponsor: Canadian Paediatric Society

Brief Summary

Active metropolitan area surveillance for hospital admissions related to invasive infection with Neisseria meningitidis will be conducted at the 12 centers in the IMPACT network in collaboration with Public Health officials, local infection specialists and infection control practitioners during the interval from January 1, 2016 to December 31, 2022.

Detailed Description

The objectives are 3-fold, including:

1. description of affected children and adults and the nature and outcome of the infection episodes

2. incidence rate determination in defined populations, by age, serogroup and study year

3. detailed study of the organisms recovered from cases

Study Timeline

• Study Start: 2016-01
• Study First Submitted: 2019-11-28
• Study First Submitted QC: 2019-11-28
• Study First Posted: 2019-12-03
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-04
• Last Update Posted: 2022-04-11
• Primary Completion: 2022-12-31
• Study Completion: 2022-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

Neisseria meningitidis isolated or detected by PCR from a normally sterile body site or fluid, such as blood, CSF, joint fluid, pleural, peritoneal, pericardial fluid or tissue biopsy -

Exclusion Criteria

patients diagnosed based only on

1. clinical signs, gram stain, or antigen test
2. meningococci isolated only from respiratory tract, including conjunctiva, sinuses, middle ear/mastoid, throat, peritonsillar abscess, cervical lymph node, tracheal aspirate, bronchial lavage etc -

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Laboratory confirmed invasive meningococcal cases.	End of 2021	Laboratory confirmed invasive meningococcal cases.

Trial Locations

Locations (13)

Alberta Children's Hospital; 🇨🇦 Calgary, Alberta, Canada

Stollery Children's Hospital; 🇨🇦 Edmonton, Alberta, Canada

BC Children's Hospital; 🇨🇦 Vancouver, British Colombia, Canada

Children's Hospital Research Institute of Manitoba; 🇨🇦 Winnipeg, Manitoba, Canada

Eastern Health Janeway Children's and Rehabilitation Centre; 🇨🇦 Saint John's, Newfoundland and Labrador, Canada

IWK Health Centre; 🇨🇦 Halifax, Nova Scotia, Canada

Children's Hospital of Eastern Ontario; 🇨🇦 Ottawa, Ontario, Canada

The Hospital for Sick Children; 🇨🇦 Toronto, Ontario, Canada

CHU- Sainte Justine; 🇨🇦 Montréal, Quebec, Canada

Montreal Children's Hospital; 🇨🇦 Montréal, Quebec, Canada

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