Consuming Grass Finished Lamb Improves Blood Plasma ω-3 Fatty Acid Response Among Healthy Consumers.

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Grass fed lamb

• Registration Number: NCT06607354
• Lead Sponsor: Queen's University, Belfast

Brief Summary

This study will investigate the impact of consuming grass-finished lamb meat on blood omega-3 PUFAs and cardiovascular risk factors compared to concentrate-finished lamb meat. Healthy volunteers will consume three portions of lamb meat/week from a grass-finished meat treatment or a concentrate-finished meat treatment for four weeks. Blood samples will be taken at weeks zero and four. The primary outcome is to assess difference in change in omega-3 PUFA concentration in plasma and platelets between treatment groups. The secondary outcome is to assess between groups differences in change in cardiovascular disease risk factors including blood pressure, BMI and lipids among healthy individuals.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-06-20
• Primary Completion: 2019-12-13
• Study Completion: 2019-12-13
• Status Verified: 2024-09
• Study First Submitted: 2024-09-09
• Study First Submitted QC: 2024-09-18
• Last Update Submitted: 2024-09-18
• Study First Posted: 2024-09-23
• Last Update Posted: 2024-09-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Healthy male and female volunteers aged between 18-64 years old.

Exclusion Criteria

• Participants with a BMI of <18.5 km/m² and greater than >35 km/m².
• Participants who take prescribed medication, including statins to reduce LDL cholesterol, and any form of dietary supplements (excluding vitamin D).
• People who smoke.
• Participants who consume more than two portions of fish per month.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Grass fed lamb	Grass fed lamb	Participants to consume three portions of lamb per week for four consecutive weeks. The lamb diet was grass only.

Primary Outcome Measures

Name	Time	Method
Fatty acid (%) change in blood plasma between treatments	Week 0 and week 4	Primary outcome is to assess the impact of consuming grass vs concentrate finished lamb on blood plasma response in healthy volunteers
Fatty acid change (%) in blood plasma phospholipids between treatments	Week 0 and week 4	Primary outcome is to assess the impact of consuming grass vs concentrate finished lamb on blood plasma phospholipid response in healthy volunteers

Secondary Outcome Measures

Name	Time	Method
Change in weight (kg) in participants between treatments	Week 0 and week 4	Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on weight among healthy volunteers
Change in Body Mass Index (BMI) in participants between treatments - calculated by dividing weight (kg) by height in meters squared	Week 0 and week 4	Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on weight and BMI response in healthy volunteers
Cholesterol	Week 0 and week 4	Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on total cholesterol, LDL, HDL and TAG response in healthy volunteers
Blood pressure (diastolic and systolic)	Week 0 and week 4	Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on blood pressure (diastolic and systolic) response in healthy volunteers

Trial Locations

Locations (1)

School of Biological Sciences, Queen's University Belfast; 🇬🇧 Belfast, United Kingdom