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临床试验/CTRI/2024/02/062768
CTRI/2024/02/062768尚未招募2/3 期

To evaluate the role of Jalukavacharan with Varnyakar lepa in management of Vyanga(Melasma)

DrPratiksha Dundappa Talawar1 个研究点 分布在 1 个国家目标入组 35 人开始时间: 2024年2月26日最近更新:

试验速览

阶段
2/3 期
状态
尚未招募
发起方
入组人数
35
试验地点
1
主要终点
Evaluate effect of Jalaukawacharan & Varnykar lepa in Vyanga (melasma) on the basis if assessment criteria of colour of melasma size of lesion & MASI score.

研究概览

简要总结

In Ayurveda skin diseases are included under the headings of Kshudrarogas and Kushta. Sushrutacharya was the first Acharya who had given detailed

describtion of Vyang under the chapter of “Kshudrarogaâ€.The clinical feature of Vyanga can be correlated with Melasma which is one of the common hyper pigmented disorders. The melasma is harmless condition, progression can be cosmetically and psychologically overwhelming.

Treating Melasma in modern science has become a problem and safe drugs for long term therapy are not available in modern medicine.There are treatments available but they may not have impact on malasma or clear it up completely,so its important to know what you can do to help minimize the appearance of dark spots & prevent them from getting worse.Topical steroids have been described in the management of facial melanosis  and these steroids have adverse effect.

According to Acharya Sushrut, Krodh and Shok are causative factors for development of Vyanga as these psychological factors vitiate Pitta and Vata dosha leads to develop Shyava varna mandala on face. Bhrajak pitta is important in production of varna in Avabhasini twacha (one of layer of skin).Vitiation of Pitta dosha in Vyanga, leads to Rakta dusthi producing vikruti in skin colour. In the context of Vyanga both Shodhana and local application in the form of lepa are explained. For Local application ingredients of Varnya mahakashyaya will be taken. In Ashtang Hriday, Raktamokshan chikitsa is described in the treatment of Vynaga.Jaluakawacharan (Leech Therapy) is one of the type of raktamokshan. For this study total 35 patients will be taken & duration of study is two months.An attempt will be made to evaluate efficacy of Jalaukawachran with varnyakar lepa in vyanga w.s.r.Malesma. Results will be discussed according to data.

研究设计

研究类型
Interventional
分配方式
Not Applicable
盲法
Open Label

入排标准

年龄范围
20.00 Year(s) 至 60.00 Year(s)(—)
性别
All

入选标准

  • 1 Patients with signs & symptoms of Vyanga.
  • 2 Signs & symptoms of Melasma.

排除标准

  • 1 Known case of any active skin malignancy 2 Pregnant woman 3 Patients suffering from all major systemic diseases IHD HIV Carcinoma 4 Patients having contagious infectious disease such as active tuberculosis Hepatitis B and C 5 Cases of burn & any skin allergy 6 Any lesion of other skin disease.

结局指标

主要结局

Evaluate effect of Jalaukawacharan & Varnykar lepa in Vyanga (melasma) on the basis if assessment criteria of colour of melasma size of lesion & MASI score.

时间窗: Follow up- 1st,15th, 30th ,45 th ,60 th day

次要结局

  • To observe the recurrence of melasma(After leech application- 30th,45th, 60th day)

研究者

发起方
DrPratiksha Dundappa Talawar
申办方类型
Government funding agency

研究点 (1)

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