Change and prognostic significance of cardio-renal parameters in cardiosurgical interventions
- Conditions
- N18Chronic kidney disease
- Registration Number
- DRKS00028812
- Lead Sponsor
- niversitätsmedizin Göttingen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 120
Patients in whom the indication for one of the cardiosurgical therapies was made due to a symptomatic heart disease in the indications mentioned under groups 1-5:
- Age >= 18 years
- Patients able to consent and cooperate
- Written consent to study participation
Group 1
Patients with high-grade aortic valve stenosis who receive surgical aortic valve replacement
group 2
Patients with severe mitral valve regurgitation who receive surgical mitral valve reconstruction/replacement
group 3
Patients with severe tricuspid regurgitation who receive surgical tricuspid valve reconstruction/replacement
group 4
Patients with CHD who receive ACVB surgery and do not have defects > grade 2
4A) with ejection fraction =50% (control group)
4B) with ejection fraction <40%
group 5
Patients receiving LVAD implantation
In this group, due to the limited use of the method, it is unlikely that a high number of cases will be reached, so this group will be recruited in an exploratory approach until the other groups have been completed. A maximum number of N=20 is provided.
Patients after a kidney transplant or requiring dialysis
- Chronic renal failure CKD stage > G5 (<15 ml/min according to CKD EPI formula)
- Autosomal Dominant Polycystic Kidney Disease (ADPKD)
- History of intrarenal disease (e.g. glomerulonephritis, interstitial nephritis)
- Current acute kidney injury
- Postrenal obstruction
- Need for therapy with catecholamines or inotropics at inclusion in the study
- Patients after heart transplantation
- Established precapillary pulmonary hypertension
- Circumstances that could interfere with the results of the Doppler sonographic evaluation or the biomarkers (e.g. significantly restrictive respiratory diseases, strongly fluctuating blood pressure values, etc.)
- Pregnancy or lactation
A board of two nephrologists assessed the exclusion criteria - the presence of acute renal failure and the severity of CKD.
Group 4A (control group)
- EF<50%
Group 4B
- EF=40%
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br>Evaluation of renal venous congestion in the different groups of patients receiving cardiac surgery
- Secondary Outcome Measures
Name Time Method <br>Correlation of the renal-venous congestion and the laboratory biomarkers with the renal outcome of the patients.