Case-control study: prevalence of cardiovascular riskfactors in formerly preeclamptic women and women with uncomplicated obstetric history.

Withdrawn

• Conditions: decreased elastic properties of the heart; Diastolic dysfunction; 10019280; 10018424; 10057166

• Registration Number: NL-OMON34398
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 278

Inclusion Criteria

Patients:
- women aged 30-50
- 5 to 10 year post partum
- preeclampsia in a previous pregnancy ;Controls:
- women aged 30-50
- 5 to 10 year post partum
- history of vascular uncomplicated pregnancies

Exclusion Criteria

- women with diagnosed hypertension in advance of first pregnancy
- diabetes mellitus
- auto immune disease
- pregnancy
- women who do not want to be informed about results of cardiovascular screening

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Diastolic dysfunction (echocardiographic/ NT-pro BNP)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1) Lifestyle (questionaire)<br /><br>2) Metabolic syndrom or it's components (obesity, hypertension, dyslipidaemia,<br /><br>insulin resistance)<br /><br>3) Endothelial function (FMD)<br /><br>4) Intima Media Thickness (IMT)<br /><br>5) Baroreceptor sensitivity (during Head up Tilt)<br /><br>6) Venous compliance</p><br>