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临床试验/NCT04330651
NCT04330651招募中不适用

Outcomes' Predictors in Post-Surgery Extracorporeal Life Support

University of Florence1 个研究点 分布在 1 个国家目标入组 500 人开始时间: 2004年1月最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
500
试验地点
1
主要终点
Survival

研究概览

简要总结

Extracorporeal Life Support (ECLS) may provide pulmonary and circulatory support for patients with acute heart failure refractory to conventional medical therapy. However, indications and effectiveness of ECLS engagement post-surgery remains a concern. The investigators sought to analyze indications, modality and outcomes of PS-ECLS, to identify predictors of early and midterm survival after PS-ECLS. The investigators have recorded prospectively, and analysed data of 209 consecutive PS-ECLS patients between January 2004 and December 2018. Demographic and clinical data before, during and after PS-ECLS were collected and their influence on hospital mortality and outcomes (early and midterm) will analyse. Multivariate analysis of pre PS-ECLS implantation factors (as age, female sex , insulin-dependent diabetes, pulmonary hypertension, STS, type of surgical procedure data, pre-ECLS blood lactate level) will be made for identify prognostic risk factors of in-hospital mortality. Overall survival will be analysed, at 6 months,1-year and 5-years, respectively and the factors influencing mild/term outcome will be investigated.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients underwent cardiac surgery

排除标准

  • Age < 18 years

结局指标

主要结局

Survival

时间窗: At 5 years after surgery

late survival

次要结局

  • Prognostic Factors(Late: 5 years after surgery)
  • Prognostic factors(Early: 1 month after surgery)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Massimo Bonacchi

Professor

University of Florence

研究点 (1)

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