PERsonalized Mood Augmentation Trial for Depressed Mood

Not Applicable

Completed

• Conditions: Depression

• Registration Number: NCT05662254
• Lead Sponsor: University of California, San Diego

Brief Summary

The goal of this open-label single-arm study is to test personalized behavioral intervention for depressed mood.

Detailed Description

The goal of this open-label single-arm study is to test personalized behavioral intervention for depressed mood. After an initial period (2-4 weeks) of mood and lifestyle monitoring using smartphone and smartwatch data, participants will be assigned to an evidenced-based behavioral plan that target their lifestyle for 6 weeks. The trial will evaluate changes in depressed mood, associated health behaviors and cognition.

Study Timeline

• Study Start: 2022-06-01
• Study First Submitted: 2022-12-10
• Study First Submitted QC: 2022-12-14
• Study First Posted: 2022-12-22
• Primary Completion: 2024-07-15
• Study Completion: 2024-10-11
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-24
• Last Update Posted: 2025-03-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Mild to moderate depression per PHQ9 symptom ratings

Exclusion Criteria

• active substance abuse/dependence
• psychotic disorders
• bipolar disorder
• eating disorder
• displaying acutely suicidal behaviors

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
PHQ9	12 weeks	Depression Symptoms on the Patient Health Questionnaire 9-item (PHQ9) scale, min 0 max 27 with lower scores representing better outcome

Trial Locations

Locations (1)

UC San Diego Health Psychiatry; 🇺🇸 San Diego, California, United States