The Effects of Vasodilators agents on Right Ventricular Energetics in patients with Pulmonary Hypertension: A study using Carbon-11 Acetate PET, oxygen-15 labeled water PET, and biomarkers
Not Applicable
Recruiting
- Conditions
- Pulmonary arterial hypertension
- Registration Number
- JPRN-UMIN000006314
- Lead Sponsor
- Hokkaido University Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Not provided
Exclusion Criteria
Patients with coronary artery disease life expectancy less than 1 year due to other co-morbidity paced rhythm Prior diagnostic sleep related disorder. inability to obtain informed consent pregnant or breast-feeding claustrophobia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method WHO functional class, 6-minute walk. Positron emission tomography: 11C acetate PET for evaluating myocardial oxidative metabolism and efficiency. 15O labeled water for evaluating myocardial blood flow and coronary resistance. Right heart catheterization for evaluating pulmonary arterial pressure and pulmonary arterial resistance. Echocardioghraphy, cardiac magnetic resonance imaging, ECG, and biomarkers from blood samples.
- Secondary Outcome Measures
Name Time Method