The effect of dietary supplements of alpha lipoic acid and vitamin E on stress oxidative in children with Down syndrome
Not Applicable
Completed
- Conditions
- Down syndrome.Down syndrome
- Registration Number
- IRCT2013102215111N1
- Lead Sponsor
- Exceptional Children Institute
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 105
Inclusion Criteria
confirmation of regular trisomy 21 in children by cytogenetic analysis; not on any medication or vitamin supplementation therapy for six months before the start of intervention.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method MDA. Timepoint: before intervention and after 4 months. Method of measurement: The determination of MDA levels will performed by method of Satho . In this method the reaction of MDA with Thiobarbituric acid (TBA) creates a complex which is determined spectrophotometrically.;Urinary 8-hydroxydeoxyguanosine (8OHdG). Timepoint: before intervention and after 4 months. Method of measurement: 8OHdG in urine samples will assessed using an enzyme-linked immunosorbent assay (ELISA) kit (8OHdG Quantitation, Cell Biolabs, Inc. San Diego ).
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie alpha lipoic acid and vitamin E's antioxidant effects in Down syndrome trisomy 21 patients?
How does the efficacy of alpha lipoic acid and vitamin E compare to standard-of-care antioxidants for oxidative stress in Down syndrome children?
Which biomarkers correlate with oxidative stress reduction in Down syndrome patients treated with alpha lipoic acid and vitamin E?
What are the safety profiles of alpha lipoic acid and vitamin E supplementation in pediatric Down syndrome populations?
What combination therapies with alpha lipoic acid and vitamin E show promise for oxidative stress management in Down syndrome?