Testing of Innocuousness of Benzalkonium Chloride on the Eye Concerning Possible Growth of Langerhans Cells

Phase 1

• Conditions: Eye Diseases

• Registration Number: NCT00414739
• Lead Sponsor: University of Rostock

Brief Summary

The study analysis the influence of benzalkonium chloride on the density of antigen presenting Langerhans cells. This is achieved in a double blind randomized study using in-vivo confocal microscopy to identify and quantify Langerhans cells of the human cornea in its central and peripheral part. This study design is based on observations with raised Langerhans cell density after the application of benzalkonium chloride containing eye drops in glaucoma patients.

Detailed Description

Not available

Study Timeline

• Status Verified: 2006-12
• Study First Submitted: 2006-12-21
• Study First Submitted QC: 2006-12-21
• Last Update Submitted: 2006-12-21
• Study First Posted: 2006-12-22
• Last Update Posted: 2006-12-22

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• healthy probands

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Exclusion Criteria

• eye diseases
• pregnancy and lactation period
• drug dependency

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Possible raised Langerhans cell density in the corneal epithelium

Trial Locations

Locations (1)

University of Rostock, Eye Department; 🇩🇪 Rostock, Germany