Natural History of Human Papillomavirus (HPV) Infections in Mid-Adult Women (WHIM)
- Conditions
- Papillomavirus Infections
- Registration Number
- NCT01295242
- Lead Sponsor
- University of Washington
- Brief Summary
The purpose of this study is to determine rates of oral and genital human papillomavirus (HPV) infections, and look at risk factors for HPV infection in healthy mid-adult women.
- Detailed Description
The investigators propose a longitudinal study of 500 women in order to determine rates and risk factors for HPV infections in 30-50 year old women. Participants will be followed for 6 months and will be asked to complete online questionnaires on their health, sexual behavior, HPV vaccinations, and cervical cancer screening. The investigators will ask participants to self-collect monthly vaginal swab samples and self-collect 2 oral swab samples. Women will also be asked to provide 2 blood samples. All swab samples will be tested for type-specific HPV deoxyribonucleic acid (DNA) using a polymerase chain reaction (PCR)-based assay, blood samples will be tested for HPV antibodies.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 409
- affiliated with the University of Washington (student, staff, faculty)
- willing to self-collect vaginal samples at home for HPV testing
- able to provide informed consent
- pregnant
- have had hysterectomy
- serious medical condition which prevents completion of activities of daily living
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Presence of type-specific HPV DNA in self-collected oral and vaginal swab samples once a month for 6 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Washington
🇺🇸Seattle, Washington, United States