A Phase Ib Study to Assess Safety and Efficacy of Oral Icaritin in Advanced Solid Tumors
- Registration Number
- NCT02496949
- Lead Sponsor
- Chinese Academy of Medical Sciences
- Brief Summary
to assess the safety, tolerability，PK and efficacy profile of two doses (600mg,800mg,BID) of Icaritin in advanced solid tumor patients in China
- Detailed Description
Estrogen receptor,ERa36, predominantly localizes on the plasma membrane and in the cytoplasm and mediates a membrane-initiated "nongenomic" signaling pathway. Membrane-initiated estrogen signaling has been linked to rapid responses to estrogen and generally activates signaling pathways like the mitogen-activated protein kinase/extracellular signal-regulated kinases (MAPK/ERK), phosphatidylinositol-3-kinase, and protein kinase C pathways. Preclinical study demonstrated that ERa36 was expressed in tumor cells and might be the driving force of breast cancer cell proliferation. 40% of breast cancer tumors which used to be considered as ER negative also express ERa36. In the former study the investigators found that 40% of ERa66-positive breast cancer patients express high levels of ERa36 in their tumors, and this subset of patients are less likely to benefit from tamoxifen treatment compared with those with ERa66-positive/ERa36-negative tumors.
Icaritin is a newly discovered small molecule with selective ERa36 modulating capability and the potential as a very promising new drug to treat advanced breast cancer and hepatocellular carcinoma (HCC) by targeting this nongenomic pathway. Studies showed that it can inhibit the growth of cancer cells both in vitro and in vivo. The investigators have completed the preclinical pharmacokinetic, pharmacodynamic (PK\&PD) and toxicity studies in animals and now move on to test it in a phase Ib clinical trial.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 28
Not provided
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Have a known hypersensitivity to flavonoid drugs.
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Hepatic:
- HCC patients : ALB <2.8g/dL, TB>3.0mg/dL, ALT and AST > 2.5 times the upper limit of Normal
- Advanced breast tumors or other advanced solid tumor patients: ALB >limit of normal, TB> the upper limit of normal, ALT and AST > upper limit of Normal Renal: Serum Creatinine >1.5 times the upper limit of normal. Blood test: Absolute neutrophil count (ANC) < 1.5 × 109/L, Platelet count < 90 × 109/L, Hemoglobin <9 g/dL.
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PT/APTT >1.25 times the upper limit of normal. HCC patients: PT > 5 seconds above control
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Suffered from thrombotic disease.
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Serum Ca > the upper limit of normal.
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Not recovered from toxic effects of previous anti-cancer treatments or surgery.
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Any serious or uncontrollable concomitant systemic disorder (such as unstable respiratory disorders, cardiovascular, hepatic or kidney disorders.) or active infection which will influence the clinical trial.
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CNS metastases or invade requiring treatment for unstable status or various psychiatric disorders
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Malabsorption or other disease which will affect the drug absorption,distribution,metabolism and excretion.
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Other concurrent malignancies with the exception of cervical cancer in situ or squamous cell carcinoma of the skin .
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Icaritin Icaritin 600mg,800mg two doses, Bid, continuous dosing for 56 days, to assess the safety,tolerance,pharmacokinetics and efficacy of icaritin
- Primary Outcome Measures
Name Time Method The number of patients reported adverse events 1-2 year
- Secondary Outcome Measures
Name Time Method Time to tumor progression 1-2 Years Overall survival 1-2 Years Progression free survival 1-2 Years
Trial Locations
- Locations (1)
Cancer institute & hospital, chinese academy of medical sciences
🇨🇳Beijing, Beijing, China