Exercise-induced High-sensitivity Troponin Levels as a Predictor for Obstructive Coronary Artery Disease
- Conditions
- Coronary Artery Disease
- Registration Number
- NCT02626806
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Brief Summary
1. To compare hs-TnT levels after a cardiac stress test in patients with vs. patients without CAD
2. To assess the level of post-exercise hs-TnT predicting CAD (using ROC-analysis)
3. To determine the sensitivity, specificity and accuracy of this exercise-induced hsTopT level in predicting CAD, either alone or in relation to traditional patient-related and exercise test-related metrics
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 150
Inclusion Criteria
- Patients with suspected CAD, planned for diagnostic coronary angiogram
- Patients with previous revascularization, suspected of recurrent ischemia
Exclusion Criteria
- Congestive cardiomyopathy with LV EF < 35%
- Renal failure with eGFR < 30 ml/min
- Known structural or severe valvular heart disease
- Prior CABG
- Previous ACS < 6 weeks
- Known incomplete revascularization after previous PCI
- Unstable angina or ACS (defined as unstable anginal symptoms + ECG changes or hs-TnT > 0.053 ng/L)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Presence of coronary artery stenosis more than 50% 24 hours
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
UZLeuven
🇧🇪Leuven, Belgium