Vascular Sensitivity to Adrenergic Agonists in Patients With CHF and in Healthy Subjects

• Conditions: Congestive Heart Failure

• Registration Number: NCT00782782
• Lead Sponsor: Hadassah Medical Organization

Brief Summary

Congestive Heart failure (CHF) is asociated with changes in cardiac function and vascular responses. The aim of this study is to characterize these differences. Our hypothesis is, that there are differences in vascular responses between healthy subjects and patients with CHF.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-08
• Status Verified: 2008-10
• Study First Submitted: 2008-10-26
• Study First Submitted QC: 2008-10-28
• Last Update Submitted: 2008-10-28
• Study First Posted: 2008-10-31
• Last Update Posted: 2008-10-31
• Primary Completion: 2009-12
• Study Completion: 2011-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Patients with congestive heart failure NYHA I-II
• Stable clinical condition

Exclusion Criteria

• Resting systolic blood pressure < 100
• Resting heart rate < 50
• Hypersensitivity to dexmedetomidine, phenylephrine, isoproterenol, terbutaline

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
vascular sensitivity (ED50) and response (Emax) to dexmedetomidine, phenylephrine, isoproterenol and terbutaline	3 weeks

Trial Locations

Locations (1)

Hadassah University Hospital; 🇮🇱 Jerusalem, Israel