Clot Formation and Coagulation Factors Consumption in the Clearing Fluid After Arterial Catheter Blood Sampling.
- Conditions
- Registration Number
- NCT06349551
- Lead Sponsor
- Nantes University Hospital
- Brief Summary
After blood sampling from an arterial catheter, the reinjection of the clearing fluid (a mixture of saline solution and blood) is proposed to limit blood loss. However, the status of coagulation in this clearing liquid remains poorly documented.
- Detailed Description
In the intensive care unit, blood sampling is mainly performed through an arterial catheter (radial or femoral artery). In addition to continuous arterial pressure monitoring, this provides an easy access to arterial blood without the need for venipuncture.
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Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 211
- Patient older than 18 years old
- Admitted to the ICU
- With a radial or femoral arterial catheter
- Requiring blood sampling
- Presence of a non-standard extension line: any tubing other than an arterial line intended for this purpose.
- Constitutional or acquired hemorrhagic disease,
- Major biological thrombophilia (anti-phospholipid syndrome, homozygous mutation of factor II or V, protein C, S or antithrombin deficiency),
- Thromboembolic event in progress or < 6 months,
- Bacteremia within the last 48 hours,
- Previous study participation,
- Pregnant or breast-feeding patient
- Moribund patient or patient with decision of withholding or withdrawing life-sustaining treatment
- Patient with no health insurance
- Patient under guardianship
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Composite score of the coagulation activation over time in the clearing fluid during blood sampling from an arterial catheter 5 minutes (T5) Activation of coagulation in the clearing fluid will be assessed by a composite criterion defined by:
* the presence of a macroscopic clot (binary YES or NO criterion) or
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- Secondary Outcome Measures
Name Time Method Concentration of prothrombin over time in the clearing fluid during blood sampling from an arterial catheter 5 minutes (T5) Prothrombin time will be assayed at T0, T3 and T5
Concentration of factor V over time in the clearing fluid during blood sampling from an arterial catheter 5 minutes (T5) Factor V will be assayed at T0, T3 and T5
Concentration of fibrin monomer over time in the clearing fluid during blood sampling from an arterial catheter 5 minutes (T5) Fibrin monomers will be assayed at T0, T3 and T5
Concentration of factor II over time in the clearing fluid during blood sampling from an arterial catheter 5 minutes (T5) Factor II will be assayed at T0, T3 and T5
Trial Locations
- Locations (2)
Nantes university hospital
🇫🇷Nantes, Loire-atlantique, France
Hospital center
🇫🇷Saint-Nazaire, France