Clot Formation and Coagulation Factors Consumption in the Clearing Fluid After Arterial Catheter Blood Sampling.

Registration Number
NCT06349551
Lead Sponsor
Nantes University Hospital
Brief Summary

After blood sampling from an arterial catheter, the reinjection of the clearing fluid (a mixture of saline solution and blood) is proposed to limit blood loss. However, the status of coagulation in this clearing liquid remains poorly documented.

Detailed Description

In the intensive care unit, blood sampling is mainly performed through an arterial catheter (radial or femoral artery). In addition to continuous arterial pressure monitoring, this provides an easy access to arterial blood without the need for venipuncture.
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Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
211
Inclusion Criteria
  • Patient older than 18 years old
  • Admitted to the ICU
  • With a radial or femoral arterial catheter
  • Requiring blood sampling
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Exclusion Criteria
  • Presence of a non-standard extension line: any tubing other than an arterial line intended for this purpose.
  • Constitutional or acquired hemorrhagic disease,
  • Major biological thrombophilia (anti-phospholipid syndrome, homozygous mutation of factor II or V, protein C, S or antithrombin deficiency),
  • Thromboembolic event in progress or < 6 months,
  • Bacteremia within the last 48 hours,
  • Previous study participation,
  • Pregnant or breast-feeding patient
  • Moribund patient or patient with decision of withholding or withdrawing life-sustaining treatment
  • Patient with no health insurance
  • Patient under guardianship
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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Composite score of the coagulation activation over time in the clearing fluid during blood sampling from an arterial catheter5 minutes (T5)

Activation of coagulation in the clearing fluid will be assessed by a composite criterion defined by:

* the presence of a macroscopic clot (binary YES or NO criterion) or
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Secondary Outcome Measures
NameTimeMethod
Concentration of prothrombin over time in the clearing fluid during blood sampling from an arterial catheter5 minutes (T5)

Prothrombin time will be assayed at T0, T3 and T5

Concentration of factor V over time in the clearing fluid during blood sampling from an arterial catheter5 minutes (T5)

Factor V will be assayed at T0, T3 and T5

Concentration of fibrin monomer over time in the clearing fluid during blood sampling from an arterial catheter5 minutes (T5)

Fibrin monomers will be assayed at T0, T3 and T5

Concentration of factor II over time in the clearing fluid during blood sampling from an arterial catheter5 minutes (T5)

Factor II will be assayed at T0, T3 and T5

Trial Locations

Locations (2)

Nantes university hospital

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Nantes, Loire-atlantique, France

Hospital center

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Saint-Nazaire, France

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