To study the movement of upper tooth (canine) during orthodontic treatment after injecting a preparation(i-PRF) made out of patients own blood and also study level of enzyme (Alkaline phoshatase) in patients gingival fluid (form of saliva).

Not Applicable

• Conditions: Health Condition 1: M264- Malocclusion, unspecified

• Registration Number: CTRI/2019/06/019716
• Lead Sponsor: Dr Paridhi Gupta

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1.Patients between 14-30 years of age and requiring fixed orthodontic treatment with first premolar extraction.

2.Healthy periodontal tissues (no gingival bleeding, probing depth <3mm, no periodontal bone loss)

3.No use of anti-inflammatory drugs in the month preceding the beginning of the study.

4.Patients who will give consent to be a part of the study.

5. No history of previous orthodontic treatment.

Exclusion Criteria

1.Patients with systemic disease or chronic debilitating disease that could interfere with bone metabolism.

2.Patients on long term use of systemic corticosteroids, antibiotics, calcium channel blockers.

3.Patients with cleft lip or palate.

4.Presence of periodontal bone loss or attachment loss.

5.Patients with periodontitis, untreated caries.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measure rate of canine retraction with and without i-PRF. <br/ ><br>Measure ALP levels in GCF from the sites with and without i-PRFTimepoint: Measure rate of canine retraction at 3 weeks for 2 years <br/ ><br>Measure ALP levels in GCF at day 0 (before initiation), after 24 hours and after 28 days.

Secondary Outcome Measures

Name	Time	Method
To compare the ALP levels at experimental and control site. <br/ ><br>To compare the rate of canine retraction at experimental and control site. <br/ ><br>Timepoint: Measure rate of canine retraction at 3 weeks for 2 years <br/ ><br>Measure ALP levels in GCF at day 0 (before initiation), after 24 hours and after 28 days.