Caudal Epidural Catheterization in Pediatric Renal Transplant: Effect on Hemodynamics and Pain After Surgery
- Conditions
- Renal Failure
- Interventions
- Device: B-Braun, Perifix® ONE Paed, Germany
- Registration Number
- NCT02037802
- Lead Sponsor
- Cairo University
- Brief Summary
pain control in pediatric renal transplant is a major concern. the main goal during anesthesia of renal transplant in pediatrics is to maintain hemodynamics in a range close to that of the adult donor. epidural analgesia is thought to be very effective in pain control. this study emphasises the ease of application of epidural catheter via the caudal route to the lower thoracic level; avoiding possible complications that may arise from lumbar or thoracic routes, and its effects on hemodynamics when using analgesic doses of local anesthetics and narcotics.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- 3-12 years
- end stage renal disease
- no known allergy to bupivacaine
- both sexes
- known allergy to bupivacaine
- inflammation at caudal area
- spinal cord deformity
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description caudal epidural catheterization group B-Braun, Perifix® ONE Paed, Germany 30 patients received continuous intra and post-operative caudal epidural infusion of bupivacaine 0.125% with fentanyl (2 microgram/ml) over 24 hours control group Fentanyl 30 patients didn't receive caudal epidural analgesia caudal epidural catheterization group Propofol 30 patients received continuous intra and post-operative caudal epidural infusion of bupivacaine 0.125% with fentanyl (2 microgram/ml) over 24 hours caudal epidural catheterization group Pethidine 30 patients received continuous intra and post-operative caudal epidural infusion of bupivacaine 0.125% with fentanyl (2 microgram/ml) over 24 hours control group Pethidine 30 patients didn't receive caudal epidural analgesia control group Propofol 30 patients didn't receive caudal epidural analgesia caudal epidural catheterization group Bupivacaine 30 patients received continuous intra and post-operative caudal epidural infusion of bupivacaine 0.125% with fentanyl (2 microgram/ml) over 24 hours caudal epidural catheterization group Fentanyl 30 patients received continuous intra and post-operative caudal epidural infusion of bupivacaine 0.125% with fentanyl (2 microgram/ml) over 24 hours
- Primary Outcome Measures
Name Time Method Intraoperative blood pressure from the induction of anesthesia till end of surgery at half an hour intervals measure systolic and diastolic blood pressure
- Secondary Outcome Measures
Name Time Method postoperative central venous pressure from the time of transfer of the patient to the intensive care unit at one hour intervals for 24 hours postoperative blood pressure from the time of transfer of the patient to the intensive care unit at one hour intervals for 24 hours record systolic and diastolic blood pressure every hour for the first 24 hours postoperative
postoperative heart rate from the time of transfer of the patient to the intensive care unit at one hour intervals for 24 hours intraoperative central venous pressure fromom the induction of anesthesia till end of surgery at half an hour intervals intraoperative heart rate from the induction of anesthesia till end of surgery at half an hour intervals
Trial Locations
- Locations (1)
Faculty of medicine, Cairo University
🇪🇬Cairo, Egypt