The effect of statin administration on shoulder pain and clinical course in patients with adhesive capsulitis who were diagnosed with hyperlipidemia.
- Conditions
- Diseases of the musculoskeletal system and connective tissue
Recruitment & Eligibility
- Status
- Terminated
- Sex
- All
- Target Recruitment
- 84
Subjects to the following criteria are eligible for this study.
?Patients over the age of 19 years and under 70 years of age who have been diagnosed with shoulder adhesive capsulitis and complaining symptom over 2 months are included in this study. The diagnosis of adhesive capsulitis is defined as one of the following.
i.Forward flexion below 100’
ii.External rotation below 45’
iii.Internal rotation below L1 level
?Patients with LDL cholesterol (130-159 mg / dL) who are in low risk group (0-1 risk factors) by determining the patient's cardiovascular risk factors. (Risk factors: smoking, high blood pressure, low density lipoprotein cholesterol (<40 mg / dL), family history of early onset of coronary artery disease, age (men> 45 years, women> 55 years))
?Women who are likely to become pregnant must meet the following conditions:
: At least one year has been menopause, there is no chance of pregnancy by surgery / procedure, or an acceptable contraceptive method (intrauterine device-loop, mirna, double-blocking diaphragm or condom / femdom + spermicide, oral or parenteral contraceptive,).
?Patients who understand this study and agree to participate in the study
Exclusion Criteria
To participate in this study, you must not meet the following exclusion criteria:
1.Patients with ipsilateral shoulder full thickness rotator cuff tear and labial lesion, arthritis, joint instability
2.Surgical Treatment for Ipsilateral Shoulder Disease
3.Patients with a history of ipsilateral shoulder infectious arthritis, rheumatoid arthritis, tumor, fracture
4.Patients who have previously taken statin drugs
5.Patients who have previously received intraarticular triamcinolone injections
6.Patients diagnosed with myopathy
7.Women who may be pregnant and are planning to be nursing or pregnant.
8.Lipitor tablets contain lactose, so patients with genetic problems such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption
9.alcoholics
10.Patients with personal or family history of hereditary muscle abnormalities
11.Patients with hypothyroidism
12.Patients receiving glecaprevir and fibrentasvir (marbitet tablet)
13.Patients with hypersensitivity to Lipitor, Triamcinolone Injection, and Components
14.Local infections, sepsis, infections without effective antimicrobial agents, systemic fungal infections, tuberculosis disease, herpes simplex keratitis, patients with previous neurological abnormalities
15.Posterior subcapsular cataract patient, glaucoma patient
16.Recent intestinal anastomosis, peptic ulcer, diverticulitis, schizophrenia, severe osteoporosis
17.Patients with uncontrolled hypertension with diastolic blood pressure above 100 mmHg, with electrolyte abnormalities
18.???? ??? ?? ?? (aspartate aminotransferase or alanine aminotransferase >60 IU litre)
19.Patients with abnormal liver function (aspartate aminotransferase or alanine aminotransferase> 60 IU litre)
20.patient with diabetes
21.Patients with renal impairment
22.Fat embolism patient, metastatic cancer patient, Cushing syndrome patient, epilepsy patient
23.Spontaneous thrombocytopenia, purpura
24.Herpes simplex, shingles, chickenpox
25.Patients deemed inappropriate for this test by the judgment of the person in charge of the test such as mental illness
Early termination criteria
1. Death of the patient
2. If hospitalization or treatment is necessary due to the development of a new important disease
3. If there is a limitation of shoulder ROM being treated due to trauma or disease
4. In case of omission of patient during follow-up
5. If the patient does not want the study to proceed anymore due to the occurrence of side effects.
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Shoulder functional score (ASES score )
- Secondary Outcome Measures
Name Time Method range of motion;shoulder functional scores (Constant score, KSES score),;blood test (total cholesterol, triglyceride, HDL-cholesterol, LDL-cholesterol, AST, ALT, Urea nitrogen);shoulder ultrasonography