An observational study to evaluate the role of an imaging sequence in MRI (diffusion weighted imaging) in detecting the spread of brain tumors to the spine in childre
Not Applicable
- Conditions
- Health Condition 1: C00-D49- Neoplasms
- Registration Number
- CTRI/2020/07/026523
- Lead Sponsor
- Tata Memorial hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Pediatric brain tumors showing restricted diffusion and with a propensity to cause CSF dissemination. This will include cases both before and after initiation of treatment. The tumours included will be medulloblastoma, anaplastic ependymoma, atypical teratoid rhabdoid tumour (ATRT), embryonal tumour with multilayered rosettes (ETMR), germinoma, glioblastoma multiforme (GBM), pineoblastoma and choroid plexus carcinoma.
2.Age group upto 18 years.
Exclusion Criteria
ï?§
1.Primary pediatric brain tumors which do not show diffusion restriction
2.Pediatric brain tumors not known to have cranio-spinal metastasis.
3.Patients lost on follow up.
4.No lesion detected on routine sequences and CSF studies.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The efficacy of DWI will be analysed by McNemars test since the data is paired and categorical. Sensitivity of DWI will also be analysed.Timepoint: After 10 months of accrual, patients will be followed up for 6 months and data will be analyzed at the end of this period.
- Secondary Outcome Measures
Name Time Method esions will be characterized as match, mismatch and reverse mismatch.Timepoint: After completion of data collection