A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Hospitalized Participants With Influenza A Infection

Phase 3

Terminated

Conditions: Influenza A

Interventions: Drug: Pimodivir 600 mg
Drug: Placebo
Other: SOC Treatment

Registration Number: NCT03376321

Lead Sponsor: Janssen Research & Development, LLC

Brief Summary: The purpose of this study is to evaluate the clinical and virologic benefit of pimodivir in combination with Standard-of-Care (SOC) treatment compared to placebo in combination with SOC treatment.

Detailed Description: This double-blind (neither researchers nor participants know what treatment participant is receiving) study will evaluate efficacy/safety of pimodivir in combination with SOC treatment versus placebo in combination with SOC treatment in adolescent, adult, and elderly hospitalized participants with influenza A infection. The study will be conducted in 3 phases: screening phase, double-blind treatment period of 5 days (with the possibility to extend treatment period by 5 days for participants who will enter an optional double-blind extension treatment arm), and post treatment follow-up period of 23 days. Study evaluations will include efficacy, pharmacokinetic, biomarkers, safety and tolerability. The duration of participation in study for each participant is 28 days, except for participants receiving extended treatment, for whom study duration will be up to 33 days.

Recruitment & Eligibility

Status: TERMINATED

Sex: All

Target Recruitment: 334

Inclusion Criteria

Tested positive for influenza A infection after the onset of symptoms using a polymerase chain reaction (PCR)-based or other rapid molecular diagnostic assay
Requires hospitalization to treat influenza infection and/or to treat complications of influenza infection (for example, radiological signs of lower respiratory tract disease, septic shock, central nervous system [CNS] involvement, myositis, rhabdomyolysis, acute exacerbation of chronic kidney disease, severe dehydration, myocarditis, pericarditis, ischemic heart disease, exacerbation of underlying chronic pulmonary disease, including asthma, chronic obstructive pulmonary disease [COPD], decompensation of previously controlled diabetes mellitus), including participants admitted to the Intensive Care Unit (ICU)
Enrollment and initiation of study drug treatment less than or equal to (<=)96 hours after onset of influenza symptoms
Being on invasive mechanical ventilation or having a peripheral capillary oxygen saturation (SpO2) less than (<)94 percent (%) on room air during screening. Participants with known pre-influenza SpO2 <94% must have an SpO2 decline greater than or equal to (>=)3% from pre-influenza SpO2 during screening
Having a screening/baseline National Early Warning Score 2 (NEWS2) of >=4

Exclusion Criteria

Received more than 3 doses of influenza antiviral medication (for example, oseltamivir [OST] or zanamivir), or any dose of ribavarin (RBV) within 2 weeks, prior to first study drug intake. Received intravenous (IV) peramivir more than one day prior to screening
Unstable angina pectoris or myocardial infarction within 30 days prior to screening (inclusive)
Presence of clinically significant heart arrhythmias, uncontrolled, unstable atrial arrhythmia, or sustained ventricular arrhythmia, or risk factors for Torsade de Pointes syndrome
Known severe hepatic impairment (Child Pugh C cirrhosis) or chronic hepatitis C infection undergoing hepatitis C antiviral therapy
Severely immunocompromised in the opinion of the investigator (for example, known cluster of differentiation 4 plus [CD4+] count <200 cells per cubic millimeter [cells/mm^3], absolute neutrophil count <750/mm^3, first course of chemotherapy completed within 2 weeks prior to screening, history of stem cell transplant within 1 year prior to screening, any history of a lung transplant)
Known allergies, hypersensitivity, or intolerance to pimodivir or its excipients

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Treatment Arm 1 (pimodivir + Standard-of-Care [SOC] treatment)	Pimodivir 600 mg	Participants will receive pimodivir 600 milligram (mg) orally twice daily for 5 days (on Days 1 through 5; for participants who will receive only 1 dose of pimodivir on Day 1 \[evening\], dosing will continue until the morning of Day 6) along with SOC treatment. Participants who meet all treatment extension criteria as defined in the protocol may receive an additional 5 day course of same treatment as received at study start. The SOC treatment is determined by investigator based on local practice, may include influenza antivirals and/or supportive care only. The choice to use influenza antivirals as part of SOC should be started no later than the day when participants initially receive pimodivir. An influenza antiviral as part of SOC cannot be changed (example, switching one influenza antiviral for another) during either treatment period or extension phase, with the exception that an influenza antiviral may be discontinued in case of suspected adverse event (AE).
Treatment Arm 1 (pimodivir + Standard-of-Care [SOC] treatment)	SOC Treatment	Participants will receive pimodivir 600 milligram (mg) orally twice daily for 5 days (on Days 1 through 5; for participants who will receive only 1 dose of pimodivir on Day 1 \[evening\], dosing will continue until the morning of Day 6) along with SOC treatment. Participants who meet all treatment extension criteria as defined in the protocol may receive an additional 5 day course of same treatment as received at study start. The SOC treatment is determined by investigator based on local practice, may include influenza antivirals and/or supportive care only. The choice to use influenza antivirals as part of SOC should be started no later than the day when participants initially receive pimodivir. An influenza antiviral as part of SOC cannot be changed (example, switching one influenza antiviral for another) during either treatment period or extension phase, with the exception that an influenza antiviral may be discontinued in case of suspected adverse event (AE).
Treatment Arm 2 (placebo + SOC treatment)	Placebo	Participants will receive placebo matching to pimodivir orally twice daily for 5 days (on Days 1 through 5; for participants who will receive only 1 dose of placebo on Day 1 \[evening\], dosing will continue until morning of Day 6) along with SOC treatment. Participants who meet all treatment extension criteria as defined in protocol may receive an additional 5 day course of same treatment as received at study start. The SOC treatment determined by investigator based on local practice, may include influenza antivirals and/or supportive care only. The choice to use influenza antivirals as part of the SOC should be made before randomization. The influenza antiviral should be started no later than day of first study drug intake. An influenza antiviral as part of the SOC cannot be changed (for example, switching one influenza antiviral for another) during either treatment period/extension phase, with the exception that an influenza antiviral may be discontinued in case of a suspected AE.
Treatment Arm 2 (placebo + SOC treatment)	SOC Treatment	Participants will receive placebo matching to pimodivir orally twice daily for 5 days (on Days 1 through 5; for participants who will receive only 1 dose of placebo on Day 1 \[evening\], dosing will continue until morning of Day 6) along with SOC treatment. Participants who meet all treatment extension criteria as defined in protocol may receive an additional 5 day course of same treatment as received at study start. The SOC treatment determined by investigator based on local practice, may include influenza antivirals and/or supportive care only. The choice to use influenza antivirals as part of the SOC should be made before randomization. The influenza antiviral should be started no later than day of first study drug intake. An influenza antiviral as part of the SOC cannot be changed (for example, switching one influenza antiviral for another) during either treatment period/extension phase, with the exception that an influenza antiviral may be discontinued in case of a suspected AE.

Primary Outcome Measures

Name	Time	Method
Number of Participants With Hospital Recovery Scale on Day 6	Day 6	The hospital recovery scale assesses a participant's clinical status. The scale provides 6 mutually exclusive conditions ordered from best to worst: 1) not hospitalized; 2) non-ICU hospitalization, not requiring supplemental oxygen; 3) non-ICU hospitalization, requiring supplemental oxygen; 4) admitted to the ICU, not requiring invasive mechanical ventilation; 5) requiring invasive mechanical ventilation; and 6) death.

Secondary Outcome Measures

Name	Time	Method
Viral Load Over Time	Baseline, Days 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 14 and 19	Viral load over time was measured by quantitative real time polymerase chain reaction (qRT-PCR) and viral culture in the mid-turbinate (MT) nasal swabs and endotracheal samples.
Number of Participants With Adverse Events as a Measure of Safety and Tolerability	Up to Day 33	An adverse event is any untoward medical event that occurs in a participant administered an investigational product, and it does not necessarily indicate only events with clear causal relationship with the relevant investigational product.
Number of Participants With Clinically Significant Changes in Laboratory Tests	Up to Day 33	Number of participants with clinically significant changes in laboratory tests were reported. Blood samples for hematology, serum chemistry, and urinalysis were collected at predefined time points for clinical laboratory testing.
Number of Participants With Clinically Significant Changes in Electrocardiogram (ECG)	Up to Day 33	Number of participants with clinically significant changes in Electrocardiogram (ECG) was reported.
Time to Hospital Discharge	Up to Day 33	The time to hospital discharge was defined as the time from start of study drug to hospital discharge.
Number of Participants With Adjudicated Influenza Complications	Up to Day 33	Influenza complications include pulmonary complications (such as respiratory failure, primary viral pneumonia, secondary bacterial pneumonia \[including pneumonia attributable to unusual pathogens\], exacerbations of chronic underlying pulmonary diseases such as chronic obstructive pulmonary disease \[COPD\] and asthma) and extrapulmonary complications (such as cardiovascular and cerebrovascular diseases \[for example, myocardial infarction, congestive heart failure, arrhythmia, stroke\], muscular disorders \[for example, myositis, rhabdomyolysis\], central nervous system \[CNS\] involvement, acute exacerbation of chronic kidney disease, decompensation of previously controlled diabetes mellitus, other infections \[for example, sinusitis and otitis\]).
Number of Participants With Emergence of Viral Resistance to Pimodivir	Up to Day 33	Emergence of viral resistance to Pimodivir was detected by genotyping and/or phenotyping. Nasal MT swabs and endotracheal samples were used for sequence analysis of the polymerase basic protein (PB)2 region of the influenza polymerase gene, and of neuraminidase (NA) genes for participants using an NA inhibitor (NAI) as part of their Standard of Care (SOC).
Plasma Concentration of Pimodivir	Day 1: 1 hour30minutes to 6 hours postdose, Day 3: Predose, Day 5: Predose and 1 hour30minutes to 6 hours postdose, Day 6: 12 hours postdose	Plasma concentration of Pimodivir was reported.
Number of Participants With Clinically Significant Changes in Vital Signs	Up to Day 33	Number of participants with clinically significant changes in vital signs (temperature, pulse rate, respiratory rate and blood pressure) was reported.

Trial Locations

Locations (266): Henry Ford Hospital
🇺🇸
Detroit, Michigan, United States
Military Medical Academy - Sofia
🇧🇬
Sofia, Bulgaria
MHAT Dr Stefan Cherkezov
🇧🇬
Veliko Tarnovo, Bulgaria
Hospital El Pino
🇨🇱
San Bernardo, Chile
The Third Xiangya Hospital, Central South University
🇨🇳
Changsha, China
Nanfang Hospital
🇨🇳
Guangzhou, China
Wuxi People s Hospital
🇨🇳
Wuxi, China
Henan Provincial Peoples Hospital
🇨🇳
Zhengzhou, China
Fakultni nemocnice Brno
🇨🇿
Brno, Czechia
Nemocnice Kyjov, p.o.
🇨🇿
Kyjov, Czechia
Nemocnice Na Bulovce
🇨🇿
Praha 8, Czechia
Centre Hospitalier d'Agen
🇫🇷
Agen cedex 9, France
CHU Amiens - Hopital Sud
🇫🇷
Amiens Cedex, France
Kasturba Medical College Hospital
🇮🇳
Manipal, India
Suretech Hospital and Research Centre Limited
🇮🇳
Nagpur, India
Siddhi Hospital
🇮🇳
Nashik, India
BLK Super Specialty Hospital
🇮🇳
New Delhi, India
Sir Ganga Ram Hospital
🇮🇳
New Delhi, India
Fortis Flight Lieutenant Rajan Dhall Hospital
🇮🇳
New Delhi, India
Lifepoint Multispecialty Hospital
🇮🇳
Pune, India
Sahyadri Speciality Hospital
🇮🇳
Pune, India
Hospital Civil de Guadalajara Fray Antonio Alcalde
🇲🇽
Guadalajara, Mexico
Hospital Civil de Guadalajara Dr. Juan I. Menchaca
🇲🇽
Guadalajara, Mexico
Hospital Universitario Dr Jose Eleuterio Gonzalez
🇲🇽
Mexico, Mexico
Szpital Miejski ZOZ
🇵🇱
Debica, Poland
Centrum Medyczne w Lancucie Sp.z o.o.
🇵🇱
Lancut, Poland
Limpopo Clinical Research Initiative
🇿🇦
Thabazimbi, South Africa
Hosp Clinic de Barcelona
🇪🇸
Barcelona, Spain
Hosp. Univ. Donostia
🇪🇸
Donostia-San Sebastian, Spain
Hosp. Gral. Univ. de Elche
🇪🇸
Elche, Spain
Hosp. Univ. de Getafe
🇪🇸
Getafe, Spain
Hosp. Univ. San Cecilio
🇪🇸
Granada, Spain
Hosp. Univ. Virgen de Las Nieves
🇪🇸
Granada, Spain
Hosp. Univ. de Bellvitge
🇪🇸
L'Hospitalet de Llobregat, Spain
Hosp. Univ. de La Princesa
🇪🇸
Madrid, Spain
Hosp. Univ. Ramon Y Cajal
🇪🇸
Madrid, Spain
Hosp. Clinico San Carlos
🇪🇸
Madrid, Spain
Hosp. Univ. 12 de Octubre
🇪🇸
Madrid, Spain
Hosp. Univ. La Paz
🇪🇸
Madrid, Spain
Hosp. Univ. Hm Monteprincipe
🇪🇸
Madrid, Spain
Hosp. De Mataro
🇪🇸
Mataro, Spain
Hosp. Clinico Univ. de Santiago
🇪🇸
Santiago de Compostela, Spain
Hosp. Mutua Terrassa
🇪🇸
Terrassa, Spain
Hosp. Alvaro Cunqueiro
🇪🇸
Vigo, Spain
Department for Heart Failure and Valvular Disease
🇸🇪
Malmö, Sweden
Norrlands Universitetssjukhus
🇸🇪
Umeå, Sweden
Akademiska Sjukhuset
🇸🇪
Uppsala, Sweden
Kaohsiung Medical University Chung Ho Memorial Hospital
🇨🇳
Kaohsiung, Taiwan
Bamrasnaradura Infectious Disease Institute
🇹🇭
Muang, Thailand
Srinagarind Hospital
🇹🇭
Muang, Thailand
Bumrungrad Hospital
🇹🇭
Wattana, Thailand
Hacettepe University Medical Faculty
🇹🇷
Samanpazari, Turkey
Adnan Menderes University
🇹🇷
Aydin, Turkey
Dicle University Medical Faculty
🇹🇷
Diyarbakir, Turkey
Kocaeli University Medical Faculty
🇹🇷
Kocaeli, Turkey
Karadeniz Teknik University Medical Faculty
🇹🇷
Trabzon, Turkey
Kharkiv MA of PGE Ch of inf.dis. BO Kharkiv Reg.Cl.inf.Hosp.
🇺🇦
Kharkiv, Ukraine
Kyiv Oleksandrivska Clinical Hospital
🇺🇦
Kyiv, Ukraine
CCH #1 Vinnytsia M.I. Pyrogov NMU Ch of Propaedeutics of IM
🇺🇦
Vinnytsia, Ukraine
Communal Institution Central City Hospital
🇺🇦
Zhytomyr, Ukraine
Vinaya Hospital and Research Center
🇮🇳
Mangalore, India
Sanatorio Britanico S.A.
🇦🇷
Rosario, Argentina
NZOZ Centrum Badan Klinicznych Piotr Napora Lekarze Spolka Partnerska
🇵🇱
Wroclaw, Poland
City Hospital #8
🇷🇺
Chelyabinsk, Russian Federation
Nemocnica Malacky, Nemocnicna A.S.
🇸🇰
Malacky, Slovakia
Nemocnica s poliklinikou S. Kukuru Michalovce, a.s.
🇸🇰
Michalovce, Slovakia
Nemocnica arm. generala L. Svobodu Svidnik, a.s.,
🇸🇰
Svidnik, Slovakia
Clinical Research Centre University of Cape Town
🇿🇦
Cape Town, South Africa
Johese Unitas
🇿🇦
Centurion, South Africa
Abdullah, IA
🇿🇦
Durban, South Africa
Sebastian, Peter
🇿🇦
Durban, South Africa
DJW Research
🇿🇦
Krugersdorp, South Africa
Emmed Research
🇿🇦
Pretoria, South Africa
Into Research
🇿🇦
Pretoria, South Africa
Nea Baptist Clinic
🇺🇸
Jonesboro, Arkansas, United States
UCSF Fresno
🇺🇸
Fresno, California, United States
Hopital Louis Mourier
🇫🇷
Colombes, France
Centre Hospitalier Intercommunal de Créteil
🇫🇷
Creteil cedex, France
CHU Dijon
🇫🇷
Dijon, France
Centre Hospitalier Départemental
🇫🇷
La Roche S/ Yon Cedex 9, France
CHU de Grenoble Hopital Albert Michallon
🇫🇷
La Tronche, France
CHU de Limoges Hopital Dupuytren
🇫🇷
Limoges, France
Hopital Edouard Herriot - CHU Lyon
🇫🇷
Lyon, France
Hopital Nord Marseille
🇫🇷
Marseille cedex 20, France
CHU Nantes - Hotel Dieu
🇫🇷
Nantes Cedex 1, France
CHU De Nice Hopital De l'Archet
🇫🇷
Nice Cedex 3, France
Hopital Saint Louis
🇫🇷
Paris cedex 10, France
Hôpital Bichat - Claude Bernard
🇫🇷
Paris, France
Hopital Cochin
🇫🇷
Paris, France
CHU Poitiers - Hopital la Miletrie
🇫🇷
Poitiers, France
CHU Saint Etienne Hopital Nord
🇫🇷
Saint-Etienne Cedex 2, France
Klinikum Donaustauf
🇩🇪
Donaustauf, Germany
Universitaetsklinik Erlangen
🇩🇪
Erlangen, Germany
Universitaetsklinikum Giessen und Marburg GmbH
🇩🇪
Hessen, Germany
Universitaetsklinikum Koelnt
🇩🇪
Koeln, Germany
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck
🇩🇪
Luebeck, Germany
Klinikum Weiden
🇩🇪
Weiden, Germany
Veszprem Megyei Tudogyogyintezete
🇭🇺
Farkasgyepü, Hungary
Tudogyogyintezet Torokbalint
🇭🇺
Torokbalint, Hungary
Zydus Hospital-Ahmedabad
🇮🇳
Ahmedabad, India
Rajiv Gandhi Institute of Medical Sciences
🇮🇳
Balaga, India
M S Ramaiah Memorial Hospital
🇮🇳
Bangalore, India
Apollo Hospitals International Limited
🇮🇳
Gandhinagar, India
Aware Global Hospital
🇮🇳
Hyderabad, India
S. R. Kalla Memorial General Hospital
🇮🇳
Jaipur, India
Eternal Heart Care Centre
🇮🇳
Jaipur, India
Ajanta Research Cemtre
🇮🇳
Lucknow, India
Midland Healthcare & Research Center
🇮🇳
Lucknow, India
Box Hill Hospital
🇦🇺
Box Hill, Australia
Gelre Ziekenhuizen Zutphen
🇳🇱
Zutphen, Netherlands
JM Research, SC
🇲🇽
Cuernavaca, Mexico
Barzilai Medical Center
🇮🇱
Ashkelon, Israel
Flinders Medical Centre
🇦🇺
Bedford Park, Australia
The Alfred Hospital
🇦🇺
Melbourne, Australia
University Of Maryland Medical Center
🇺🇸
Baltimore, Maryland, United States
University of Alabama at Birmingham
🇺🇸
Birmingham, Alabama, United States
Miller Children's at Long Beach Medical Center
🇺🇸
Long Beach, California, United States
Stanford University School of Medicine
🇺🇸
Stanford, California, United States
Destin Pulmonary Critical Care, PLLS.
🇺🇸
Santa Rosa Beach, Florida, United States
Northside Hospital
🇺🇸
Atlanta, Georgia, United States
Augusta University
🇺🇸
Augusta, Georgia, United States
Anne Arundel Medical Center
🇺🇸
Annapolis, Maryland, United States
Massachusetts General Hospital
🇺🇸
Boston, Massachusetts, United States
Wayne State Univ School of Medicine
🇺🇸
Detroit, Michigan, United States
Wayne State University
🇺🇸
Detroit, Michigan, United States
Western Michigan University Homer Stryker M.D. School of Medicine Center for Clinical Research
🇺🇸
Kalamazoo, Michigan, United States
William Beaumont Hospital
🇺🇸
Troy, Michigan, United States
Regents of the University of Minnesota
🇺🇸
Minneapolis, Minnesota, United States
Washington University
🇺🇸
Saint Louis, Missouri, United States
Mercury Street Medical Group, PLLC
🇺🇸
Butte, Montana, United States
Saint Michaels Medical Center
🇺🇸
Newark, New Jersey, United States
Holy Name Medical Center
🇺🇸
Teaneck, New Jersey, United States
Montefiore Medical Center PRIME
🇺🇸
Bronx, New York, United States
UC Health LLC
🇺🇸
Cincinnati, Ohio, United States
Rhode Island Hospital
🇺🇸
Providence, Rhode Island, United States
Lowcountry Infectious Diseases
🇺🇸
Charleston, South Carolina, United States
University of Texas Southwestern Medical Center
🇺🇸
Dallas, Texas, United States
DM Clinical Research
🇺🇸
Tomball, Texas, United States
Hospital Interzonal General de Agudos Dr. Jose Penna
🇦🇷
Bahia Blanca, Argentina
CEMIC (Centro de Educación Médica e Investigaciones Clínicas)
🇦🇷
C.a.b.a., Argentina
Hospital Nuestra Señora de la Misericordia
🇦🇷
Cordoba, Argentina
Hospital Cordoba
🇦🇷
Cordoba, Argentina
Hospital Privado Centro Medico de Cordoba
🇦🇷
Cordoba, Argentina
Hospital Rawson
🇦🇷
Córdoba, Argentina
Hospital San Roque
🇦🇷
Córdoba, Argentina
Sanatorio Juan XXIII
🇦🇷
General Roca, Argentina
Hospital Italiano de La Plata
🇦🇷
La Plata Lpl Lpl, Argentina
Instituto Medico Platense
🇦🇷
La Plata, Argentina
Hospital Universitario Austral
🇦🇷
Pilar, Argentina
Royal Melbourne Hospital
🇦🇺
Melbourne, Australia
Mater Hospital Brisbane
🇦🇺
South Brisbane, Australia
Townsville Hospital
🇦🇺
Townsville, Australia
AKH - Medizinische Universitat Wien
🇦🇹
Wien, Austria
SMZ Süd - Kaiser Franz Josef Spital Wien
🇦🇹
Wien, Austria
Social Medizinisches Zentrum Baumgartner Höhe - Otto Wagner Spital
🇦🇹
Wien, Austria
Institut Jules Bordet
🇧🇪
Brussel, Belgium
CHU Saint-Pierre
🇧🇪
Bruxelles, Belgium
ULB Hôpital Erasme
🇧🇪
Bruxelles, Belgium
Santa Casa de Misericordia de Belo Horizonte
🇧🇷
Belo Horizonte, Brazil
Cardresearch - Cardiologia Assistencial
🇧🇷
Belo Horizonte, Brazil
Infection Control Ltda
🇧🇷
Brasil, Brazil
Associacao Hospitalar Beneficente Sao Vicente de Paulo - Hospital Sao Vicente de Paulo
🇧🇷
Passo Fundo, Brazil
Hospital das Clinicas de Porto Alegre
🇧🇷
Porto Alegre, Brazil
Irmandade Santa Casa de Misericordia de Porto Alegre
🇧🇷
Porto Alegre, Brazil
Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS
🇧🇷
Porto Alegre, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base
🇧🇷
Sao Jose do Rio Preto, Brazil
Irmandade Santa Casa de Misericordia de Sao Paulo
🇧🇷
Sao Paulo, Brazil
Fundacao Jose Luiz Egydio Setubal
🇧🇷
Sao Paulo, Brazil
Hosp. Da Luz Lisboa
🇧🇷
Sao Paulo, Brazil
SHATPPD - Ruse Ltd.
🇧🇬
Ruse, Bulgaria
SHATPPD - Sofia District EOOD
🇧🇬
Sofia, Bulgaria
Fifth Multiprofile Hospital for Active Treatment - MHAT - Sofia EAD
🇧🇬
Sofia, Bulgaria
Multiprofile Hospital for Active Treatment - MHAT Lyulin EAD
🇧🇬
Sofia, Bulgaria
University of British Columbia
🇨🇦
Vancouver, British Columbia, Canada
Health Sciences North Horizon Sante-Nord
🇨🇦
Sudbury, Ontario, Canada
Hospital Dr Sotero del Rio
🇨🇱
Puente Alto, Chile
Shree Giriraj Multispeciality Hospital
🇮🇳
Rajkot, India
BAPS Pramukhswami Hospital
🇮🇳
Surat, India
Haemek Medical Center
🇮🇱
Afula, Israel
Soroka University Medical Center
🇮🇱
Beersheba, Israel
Bnai Zion Medical Center
🇮🇱
Haifa, Israel
Rambam Health Care Campus
🇮🇱
Haifa, Israel
Wolfson Medical Center
🇮🇱
Holon, Israel
Hadassah University Hospita Ein Kerem
🇮🇱
Jerusalem, Israel
Sapir Medical Center, Meir Hospital
🇮🇱
Kfar-Saba, Israel
Galilee Medical Center
🇮🇱
Nahariya, Israel
Rabin Medical Center Beilinson Campus
🇮🇱
Petach Tikva, Israel
Chaim Sheba Medical Center
🇮🇱
Ramat Gan, Israel
Kaplan Medical Center
🇮🇱
Rechovot, Israel
Ziv Medical Center
🇮🇱
Safed, Israel
Tel Aviv Sourasky Medical Center
🇮🇱
Tel Aviv, Israel
Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
🇮🇹
Milano, Italy
Fondazione IRCCS Ospedale Maggiore Policlinico,Mangiagalli e Regina Elena
🇮🇹
Milano, Italy
Ospedale San Giuseppe - Fatebenefratelli
🇮🇹
Milano, Italy
Ospedale San Raffaele- Sede Distaccata Ospedale S. Raffaele Turro
🇮🇹
Milano, Italy
ASST Grande Ospedale Metropolitano Niguarda
🇮🇹
Milano, Italy
AOU Policlinico di Modena
🇮🇹
Modena, Italy
Azienda Socio Sanitaria Territoriale di Monza Presidio San Gerardo
🇮🇹
Monza, Italy
Azienda Ospedaliera Universitaria Maggiore della Carità
🇮🇹
Novara, Italy
Azienda Ospedaliero Universitaria Policlinico Paolo Giaccone
🇮🇹
Palermo, Italy
Lazzaro Spallanzani IRCCS
🇮🇹
Roma, Italy
Azienda Ospedaliera Universitaria Integrata Verona
🇮🇹
Verona, Italy
Chungbuk National University Hospital
🇰🇷
Cheongju-si, Korea, Republic of
Yonsei University Wonju Severance Christian Hospital
🇰🇷
Gangwon-do, Korea, Republic of
Hospital Infantil de Mexico Federico Gomez
🇲🇽
Ciudad De Mexico, Mexico
Korea University Ansan Hospital
🇰🇷
Gyeonggi-do, Korea, Republic of
The Catholic university of Korea, St. Vincent's Hospital
🇰🇷
Gyeonggi-do, Korea, Republic of
Hallym University Dongtan Sacred Heart Hospital
🇰🇷
Hwaseong-si, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷
Incheon, Korea, Republic of
The Catholic University of Korea, Incheon St. Mary's Hospital
🇰🇷
Incheon, Korea, Republic of
Dong-A University Hospital
🇰🇷
Pusan, Korea, Republic of
Korea University Anam Hospital
🇰🇷
Seoul, Korea, Republic of
Konkuk University Medical Center
🇰🇷
Seoul, Korea, Republic of
Asan Medical Center
🇰🇷
Seoul, Korea, Republic of
Hallym University Kangnam Sacred Heart Hospital
🇰🇷
Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷
Seoul, Korea, Republic of
Regional Hospital of Liepaja
🇱🇻
Liepaja, Latvia
Hospital of Rezekne
🇱🇻
Rezekne, Latvia
Centre of Tuberculosis and Lung Diseases
🇱🇻
Riga District, Latvia
Children's Clinical University Hospital
🇱🇻
Riga, Latvia
Riga East Clinical University Hospital
🇱🇻
Riga, Latvia
Pauls Stradins Clinical University Hospital
🇱🇻
Riga, Latvia
Vidzemes Hospital
🇱🇻
Valmiera, Latvia
Klaipeda University Hospital
🇱🇹
Klaipeda, Lithuania
Siauliai Republican Hospital, Public Institution
🇱🇹
Siauliai, Lithuania
Infectious Diseases Center of Vilnius University Hospital Santaros klinikos
🇱🇹
Vilnius, Lithuania
Hospital Sultanah Bahiyah
🇲🇾
Alor Setar, Malaysia
Hospital Queen Elizabeth
🇲🇾
Kota Kinabalu, Malaysia
Hospital Sultanah Nur Zahirah
🇲🇾
Kuala, Malaysia
Hospital Umum Sarawak
🇲🇾
Kuching, Malaysia
Hospital Miri
🇲🇾
Miri, Malaysia
Hospital Tuanku Jaafar
🇲🇾
Seremban, Malaysia
Hospital Sibu
🇲🇾
Sibu, Malaysia
Hospital Sungai Buloh
🇲🇾
Sungai Buloh, Malaysia
Hospital Taiping
🇲🇾
Taiping, Malaysia
Albert Schweitzer Ziekenhuis
🇳🇱
Dordrecht, Netherlands
Jeroen Bosch Ziekenhuis
🇳🇱
s-Hertogenbosch, Netherlands
UMC Utrecht
🇳🇱
Utrecht, Netherlands
Christchurch Hospital
🇳🇿
Christchurch, New Zealand
Waikato Hospital
🇳🇿
Hamilton, New Zealand
Tauranga Hospital
🇳🇿
Tauranga, New Zealand
Wellington Hospital
🇳🇿
Wellington, New Zealand
Clinica Peruano Americana S.A
🇵🇪
Trujillo, Peru
Clinical Infectious Diseases Hospital n. a. S.P. Botkin
🇷🇺
St. Petersburg, Russian Federation
LLC Reafarm
🇷🇺
Stavropol, Russian Federation
Clinical Hospital #3
🇷🇺
Yaroslavl, Russian Federation
National University Hospital
🇸🇬
Singapore, Singapore
Tan Tock Seng Hospital
🇸🇬
Singapore, Singapore
Changi General Hospital
🇸🇬
Singapore, Singapore
DFNsP Bratislava
🇸🇰
Bratislava, Slovakia
National Taiwan University Hospital
🇨🇳
Taipei, Taiwan
Tri-Service General Hospital
🇨🇳
Taipei, Taiwan
Taipei Medical University-Wan Fang Hospital
🇨🇳
Taipei, Taiwan
Siriraj Hospital
🇹🇭
Bangkok, Thailand
Poltava Regional Clinical Hospital HSEI of Ukraine Ukrainian Medical Stomatological Academy
🇺🇦
Poltava, Ukraine
Aberdeen Royal Infirmary
🇬🇧
Aberdeen, United Kingdom
Western General Hospital
🇬🇧
Edinburgh, United Kingdom
Leeds General Infirmary
🇬🇧
Leeds, United Kingdom
North Manchester General Hospital
🇬🇧
Manchester, United Kingdom
Musgrove Park Hospital
🇬🇧
Taunton, United Kingdom
Bach Mai Hospital
🇻🇳
Hanoi, Vietnam
National Hospital for Tropical Diseases
🇻🇳
Hanoi, Vietnam
Thanh Nhan Hospital
🇻🇳
Hanoi, Vietnam
Children's Hospital 1
🇻🇳
Ho Chi Minh, Vietnam
Children's Hospital 2
🇻🇳
Ho Chi Minh, Vietnam
Nguyen Tri Phuong Hospital
🇻🇳
Ho Chi Minh, Vietnam