Is progression of arteriosclerosis in ESRD patients inhibited by nocturnal hemodialysis of renal transplantation?

Completed

• Conditions: cardiovascular disease in hemodialysis patients; vascular calcification in patients with end-stage renal disease; 10011082; 10029149; 10003216

• Registration Number: NL-OMON47285
• Lead Sponsor: Dianet Dialysecentra

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2018-12-12
• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 181

Inclusion Criteria

1. patients who start with nocturnal home hemodialysis
2. patients who undergo an renal transplant from a living donor
3. patients treated with conventional hemodialysis
4. patients treated with peritoneal dialysis
NB patients aged 18-80 yr are included

Exclusion Criteria

- life expectancy < 3 months
- claustrophobia
- allergy to iodinated contrast
- treatment incompliance, i.e. non-adherence to dialysis regimens and drug use
- GFR < 30 ml/min (according to MDRD formula) in renal transplant patients
- pregnancy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- individual change in coronary artery calcification score</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- individual change in pulse wave velocity<br /><br>- change in in calcification score in aorta and iliac arteries<br /><br>- change in coronary stenosis and left ventricular function<br /><br>- association between calciumphosphate homeostasis, inflammatory parameters and<br /><br>calcification inhibitors on the one hand and change in coronary artery<br /><br>calcification score on the other hand</p><br>