Interactions between central and peripheral respiration's control cells in humans with high blood pressure.

Not Applicable

Recruiting

• Conditions: Hypertension; Respiratory - Normal development and function of the respiratory system; Cardiovascular - Hypertension

• Registration Number: ACTRN12619001767190
• Lead Sponsor: niversity of Auckland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-12-12
• Last Update Posted: 28 March 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Patients with essential hypertension (Stage 2, treated controlled or uncontrolled; office SBP greater than 140 mmHg or DBP greater than 90 mmHg);
- Normotensive controls (office SBP less than 120 mmHg and DBP less than 80 mmHg);
- BMI less than 35 kg.m2.

Exclusion Criteria

•Significant arrhythmias (e.g., atrial fibrillation, previous VT / significant ventricular ectopy)
•Significant valvular heart disease
•Previous coronary artery bypass surgery
•Primary angioplasty for acute ST elevation
•Myocardial infarction
•Severe left ventricular dysfunction
•Recent (< 3 months) ischemic stroke
•Current smoker
•Body mass index < 18 kg/m2.
•Current pregnancy
•Users of recreational drugs
•Abusers of alcohol
•Inability to fully or appropriately provide consent (e.g., language issue, reading capability)
•Underlying medical conditions, which in the opinion of the Investigator place the participant at unacceptably high risk for participating in the study.
Chronic and systemic illness including:
•Severe respiratory disease (e.g., chronic obstructive pulmonary disease);
•Severe, uncontrolled type II diabetes;
•Current active treatment for cancer
•Connective tissue or inflammatory disease
•Neurological disease
•Infection or pyrexial illness
•Uncontrolled thyroid disorders
•Renal impairment (e.g., chronic kidney disease with creatinine clearance <29 ml/min)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Muscle sympathetic nerve activity as assessed by microneurography.<br><br>[: Assessed at multiple timepoints during a single experimental session: hypercapnic hyperoxia (primary timepoint), isocapnic hypoxia, hypercapnic hypoxia, isocapnic hyperoxia and hypocapnic hyperoxia<br>]

Secondary Outcome Measures

Name	Time	Method
Blood pressure as assessed by finger photoplethysmography.[Assessed at multiple timepoints during a single experimental session: hypercapnic hyperoxia, isocapnic hypoxia, hypercapnic hypoxia, isocapnic hyperoxia and hypocapnic hyperoxia]