Effects of Different Kinds of Antihypertensive Drugs on Dynamic Hemodynamic Changing of During Laparoscopic Gastrectomy and Laparotomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 59
- 试验地点
- 1
- 主要终点
- SVV
研究概览
简要总结
SVV is clinically affected by a variety of factors, such as abdominal pressure, body position, tidal volume, type and temperature of liquid treatment, etc. There are few reports on the effects of drugs on SVV.
In clinical anesthesia, surgical stimulation and stress can affect patient hemodynamic stability, used in intraoperative vascular active drug is inevitable, they shrink or dilate blood vessels, speed up or slow down the heart rate, makes the ventricular preload and corresponding changes in the SV. Now, there is a study on SVV and PPV in patients with hypertension, but there are few reports on the effect of blood pressure drugs on the changes in patients' threshold.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •body mass index (BMI) 18-26kg/m
- •Hypertension and non-hypertensive patients
- •diabetic no complications
- •no lung, liver, kidney and blood system diseases
- •preoperative examination is basically normal.
排除标准
- •Any type of arrhythmia, intraoperative need for other vasoactive drug intervention.
研究组 & 干预措施
Group N
the group treated with nicardipine
干预措施: Nicardipine (Drug)
Group U
the group treated with Urapidil
干预措施: Urapidil (Drug)
结局指标
主要结局
SVV
时间窗: The period between the begining of anesthesia and the end of operation.
stroke volume variation
次要结局
未报告次要终点
研究者
Yi Liu
Attending doctor
Chinese PLA General Hospital