Effects of Different Kinds of Hypotensive Drugs on Dynamic Hemodynamic Changing in Patients Under Surgeries
- Registration Number
- NCT03497351
- Lead Sponsor
- Chinese PLA General Hospital
- Brief Summary
SVV is clinically affected by a variety of factors, such as abdominal pressure, body position, tidal volume, type and temperature of liquid treatment, etc. There are few reports on the effects of drugs on SVV.
In clinical anesthesia, surgical stimulation and stress can affect patient hemodynamic stability, used in intraoperative vascular active drug is inevitable, they shrink or dilate blood vessels, speed up or slow down the heart rate, makes the ventricular preload and corresponding changes in the SV. Now, there is a study on SVV and PPV in patients with hypertension, but there are few reports on the effect of blood pressure drugs on the changes in patients' threshold.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 59
- ASA Ⅰ-Ⅲ
- body mass index (BMI) 18-26kg/m2.
- Hypertension and non-hypertensive patients
- diabetic no complications
- no lung, liver, kidney and blood system diseases
- preoperative examination is basically normal.
- Any type of arrhythmia, intraoperative need for other vasoactive drug intervention.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group U Urapidil the group treated with Urapidil Group N Nicardipine the group treated with nicardipine
- Primary Outcome Measures
Name Time Method SVV The period between the begining of anesthesia and the end of operation. stroke volume variation
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Chinese PLA General Hospital
🇨🇳Beijing, Haidian, China