Cardiometabolic Risk of Shiftwork

Terminated

• Conditions: Circadian Dysregulation; Shift-Work Sleep Disorder; Sleep Deprivation
• Interventions: Behavioral: sleep extension & circadian alignment

• Registration Number: NCT01264913
• Lead Sponsor: University of Chicago

Brief Summary

The overall goal of the present application is to test the hypothesis that shift workers, who are chronically exposed to circadian misalignment and sleep loss, have a higher cardio-metabolic risk than day workers, and that the accumulated sleep debt and the degree of circadian misalignment both predict their elevated cardio-metabolic risk.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2009-08
• Study First Submitted: 2010-12-13
• Study First Submitted QC: 2010-12-20
• Study First Posted: 2010-12-22
• Primary Completion: 2015-03
• Study Completion: 2015-03
• Status Verified: 2016-09
• Last Update Submitted: 2016-09-29
• Last Update Posted: 2016-10-03

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• Day workers and shift workers at the University of Chicago, University of Chicago Medical Center, or another Chicago area medical center who have maintained their work schedule (at least 30 hours/week) for at least 6 months.
• Individuals who have been shift workers for less than 10 years; body mass index <40 kg/m2;
• No major illness
• No history of psychiatric, endocrine, cardiac or sleep disorders
• Those with hypertension or dyslipidemia will be included if these conditions are controlled by a stable treatment.
• Women taking oral contraceptive or hormonal replacement therapy will be included only if they plan to stay on a stable regimen throughout the study.
• Age must be between 18 and 50 years

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Exclusion Criteria

• Individuals who have worked at the University of Chicago, University of Chicago Medical Center, or another Chicago area medical center in their current position for less than 6 months.
• Individuals who have been shift workers for more than 10 years
• BMI>40 kg/m2
• Individuals with a major illness (e.g. diabetes, sleep disorder)

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Shift Workers	sleep extension & circadian alignment	-
Day Workers	sleep extension & circadian alignment	-

Trial Locations

Locations (1)

The University of Chicago; 🇺🇸 Chicago, Illinois, United States