Evaluation of the Lungs of Normal Individuals With Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing and Bronchial Wall Biopsy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 196
- 试验地点
- 1
- 主要终点
- Evaluate etiology of lung diseases
研究概览
简要总结
The purpose of this study is to obtain biologic materials from the blood and lungs of normal individuals to establish a set of normal range for various parameters. These will provide important information when applied to individuals with various pulmonary diseases, and will help in understanding of the etiology and pathogenesis of various lung diseases.
详细描述
Study procedures will be performed at the Weill Cornell Medical College-New York Presbyterian Hospital and/or Weill Greenburg York Avenue Building. Study procedures done elsewhere that are within the protocol timeframe will be accepted if seen fit by the investigators so that they are not repeated unnecessarily. Study individuals who undergo bronchoscopy with intravenous administration of sedatives and analgesia may be required to stay overnight. Bronchoscopy is normally an ambulatory procedure. The subject is observed after the bronchoscopy, including vital signs and level of consciousness, until they are back to baseline. An overnight stay would only be required if the individual was not, in the judgment of the attending physician, safe to be discharged as is standard practice. Follow up of all participants are carried out by telephone within 1 wk following the procedure.
Rockefeller University has been added as a second site.
Individuals undergoing bronchoscopy without intravenous administration of sedatives and analgesia are not required to stay overnight due to the lack of administration of CNS-altering drugs and the limited sampling involved (tracheal brushes only).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All study subjects should be able to provide informed consent
- •Males or females ages 18 years and older.
- •Must provide HIV informed consent.
- •Non-smokers, ex-smokers and smokers.
排除标准
- •Individuals not deemed in good overall health by the investigator will not be accepted into the study.
- •Drug and/or alcohol abuse within the past six months.
- •Individuals with history of chronic lung disease, including asthma or with recurrent or recent (within three months) acute pulmonary disease will not be accepted into the study.
- •Individuals with allergies to atropine or any local anesthetic will not be accepted into the study.
- •Individuals with allergies to pilocarpine, isoproterenol, terbutaline, atropine or aminophylline will not be accepted into the study
- •Females who are pregnant or nursing will not be accepted into the study
结局指标
主要结局
Evaluate etiology of lung diseases
时间窗: 9/31/2012
We hope to learn more about the specific causes of lung disease, how lung disease manifests and progresses, and how lung disease can be treated.
次要结局
- Effect of smoking on the genes of airway epithelial cells(9/31/2012)