Effect of Perioperative Sivelstat Administration for Liver Resection
- Registration Number
- NCT00738348
- Lead Sponsor
- Kochi University
- Brief Summary
It is reported that sivelstat improved and preserved the postoperative renal function in the orthopedic management. Moreover because sivelstat reduced the migration of neutrophil, it improved acute lung injury. During liver resection, Pringle maneuver, clamping the hepatoduodenal ligament, was performed. Pringle maneuver causes reperfusion injury of the liver. We have a hypothesis that sivelstat prevent the warm shock of reperfusion injury of the liver by Pringle maneuver.
- Detailed Description
Whether the incidence of postoperative morbidities, such as liver failure, renal failure, or congestive heart failure, was reduced by administration of perioperative sivelstat.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- liver disease which surgical management was indicated
Exclusion Criteria
- weight loss greater than 10 per cent during the previous 6 months, signs of distant metastasis, or of respiratory, renal or heart disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 2 sivelstat 250mL of 5% glucose plus 300mg of sivelstat was infected through the vein at 10mL per an hour 1 glucose 250mL of 5% glucose was injected though the vein at 10mL per an hour
- Primary Outcome Measures
Name Time Method The incidence of liver damage due to reperfusion injury by Pringle maneuver was measured by several cytokines, including IL-8, IL-6, and HMGB-1. during hospitalization
- Secondary Outcome Measures
Name Time Method The duration of ICU stay and hospital stay, postoperative complications, and the liver damage at 6 POD, measuring hepato-biliary enzyme during hospitalization
Trial Locations
- Locations (1)
Kochi Medical School
🇯🇵Kohasu-Okocho, Nankoku, Japan