The effects of exercise based on cadiopulmonary exercise training (CPX) in depression and exploring the mechanisms involved in the effects on PBMC mitochondria of depressio
- Conditions
- major depressive disorder, persistent depressive disorder
- Registration Number
- JPRN-UMIN000025431
- Lead Sponsor
- Hokkaido University
- Brief Summary
We developed an exercise program based on patients' individual level of anaerobic threshold, a submaximal index of aerobic capacity measured by cardiopulmonary exercise testing. We found that in patients diagnosed with major depressive disorder or persistent depressive disorder, our exercise program resulted in a clinically significant reduction in depressive symptoms at week 8, which was maintained at week 16.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 15
Not provided
1. Patients with severe depression (HAM-D score 20 or more) 2. Patients expressing serious suicidal thoughts 3. Patients with YMRS score 13 or more 4. Patients with inflammatory disease 5. Patients with malignant tumor 6. Patients who can't take exercise using exercise bike due to orthopedic disease 7. Patients who have usually take exercise at fixed intervals 8. Patients treated with dialysis for chronic renal failure 9. patients whom principal investigators consider are not eligible
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method amount of change in HAM-D before and 8,16 weeks after exercise sessions
- Secondary Outcome Measures
Name Time Method