Metabolomic Analysis of the Impacts of Hydration Status on Exercise Performance

Not Applicable

Terminated

• Conditions: Dehydration; Salivary Osmolar Concentration; Physical Exertion; Urinary Osmolar Concentration
• Interventions: Dietary Supplement: Sports Drink; Dietary Supplement: Kona Deep; Dietary Supplement: Spring Water

• Registration Number: NCT02486224
• Lead Sponsor: University of Arizona

Brief Summary

Kona Deep is bottled water extracted from a depth of 3000 feet off the cost of Kona, Hawaii. Kona Deep claims that this unique source provides water that is "naturally free of pathogens, chemicals and pollutants and rich in nutrients and minerals that are readily absorbed by the body". The investigators wish to examine Kona Deep's claim that this water is "beneficial to the human body" by testing the impact of drinking Kona Deep on exercise performance and recovery. Subjects will be exercised to a safe level of dehydration and then will be rehydrated with Kona Deep water, or commercially available bottled spring water or Gatorade as controls. Subjects will perform a simple exercise to evaluate peak power performance. This measurement will be compared between rehydration methods for significant differences.

Detailed Description

Exercise-induced dehydration is very common in athletes and regularly active individuals. Hypohydration, if sufficiently severe, can negatively impact physical performance and mental capacity. Development of an efficient rehydration therapy could prove beneficial in these circumstances. Multiple animal studies have shown the positive effects of desalinated deep-sea mineral water on various physiological conditions. The beneficial effects of deep-sea mineral water may be attributed to its unique mineral composition, particularly magnesium, which is highly abundant in deep-sea water. The investigators wish to evaluate whether a similar response occurs in post-exercise rehydration using deep ocean water from a different source. Kona Deep is marketed as Hawaiian glacier water drawn from a depth of 915 m off the Kona coast that is naturally rich in electrolytes and nutrients, and that is free of mercury, harmful bacterial, and pollutants, making it a desired drinking water source. Accordingly, the investigators will investigate whether subjects administered Kona Deep following an exercise challenge undergo more rapid rehydration and demonstrate higher peak power production compared to subjects administered commercially available liquids. Euhydrated subjects in this study will be exposed to an exercise-challenge protocol (stationary biking) under warm conditions (30°C) to accelerate dehydration. Dehydration will be measured as a body mass loss of 3-5% (maximum exercise time will be 180 minutes). A body mass loss of 3% is the minimal amount lost during a similar exercise-dehydration protocol but where significance was still observed in exercise performance, recovery, and physiological parameters. During the post-exercise recovery period, subjects will consume one of three liquids in a volume equivalent to 1.5 times the body mass lost. Rehydration measured by salivary and urinary osmolality and exercise recovery will be measured such as oxygen consumption (VO2) at 60% estimated maximal heart rate and peak power production by contraction of the knee extensors before exercise, immediately after exercise, and after the rehydration period.

Study Timeline

• Study First Submitted: 2015-06-08
• Study First Submitted QC: 2015-06-26
• Study First Posted: 2015-07-01
• Study Start: 2015-09
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31
• Status Verified: 2021-10
• Last Update Submitted: 2021-10-05
• Last Update Posted: 2021-10-14

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 17

Inclusion Criteria

• Non-smokers, BMI: 18.5-24.9, 20-25 years of age, physically active

Exclusion Criteria

• prescription medications, BMI > 24.9

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Sports Drink	Sports Drink	Subjects will receive commercially available Sports Drink post-exercise
Kona Deep	Kona Deep	Subjects will receive Kona Deep post-exercise
Spring Water	Spring Water	Subjects will receive commercially available Spring Water post-exercise

Primary Outcome Measures

Name	Time	Method
Change in Salivary Osmolar Concentration during Exercise, Post-Exercise, Post-Rehydration	0-180 minutes	Saliva will be collected at regular intervals throughout the study protocol

Secondary Outcome Measures

Name	Time	Method
Change in Lower body muscle power Pre-Exercise, Post-Exercise, Post-Rehydration	0-180 minutes	Lower body muscle power will be determined prior to, immediately following exercise and immediately following rehydration. This will be executed using a Biodex Dynamometer to determine single leg extension and flexion torque.
Change in Urinary Osmolar Concentration during Exercise, Post-Exercise, Post-Rehydration	0-180 minutes	Urine will be collected prior to, immediately following exercise and immediately following rehydration.

Trial Locations

Locations (1)

Ina A. Gittings Building; 🇺🇸 Tucson, Arizona, United States