Rehabilitation of Facial Emotion Recognition in Alzheimer's Disease and Study of the Consequences on Gaze Strategy, Behavior Disorders and Family Caregivers' Burden
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Facial emotion recognition (FER) performances (dynamic set)
研究概览
简要总结
EYE-TAR(AD+) is an observational study based on the same design as the princeps EYE-TAR(MA) study, but with a larger number of patients and including an additional evaluation of Facial emotion recognition (based on a more ecological material), in order to reinforce conclusions of the study EYE-TAR(MA) https://doi.org/10.1016/j.npg.2020.08.003.
The main objective is to confirm that facial emotion recognition can be improved in AD using the "Training of Affect Recognition program" (TAR).
The Secondary Objectives are to:
Evaluate the impact of the "Training of Affect Recognition program" (TAR) on oculomotor behavior in a situation of social cognition, on behavioral disorders and on caregiver burden.
Confirm that improvement in facial emotion recognition is related to modification of observation strategies.
Confirm the link between improved recognition of facial emotions, reduced behavioral disorders and caregiver burden.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or Female.
- •AD diagnosed according to l'IWG-2 (Dubois & al. 2014) criteria,
- •Mini-Mental State (MMS-E) ≥15
- •Subject accompanied by a family caregiver and whose participation in a cognitive stimulation workshop was recommended in Memory Centre of the RAINIER Centre (Princesses Grace Hospital - Monaco)
- •Written informed consent signed by patient and family caregiver.
排除标准
- •General anaesthesia within 3 months.
- •History of psychiatric and/or neurological disorder (other than the diagnosed neurodegenerative pathology);
- •History of alcoholism or drug addiction
- •Ophthalmological or neurological problems preventing a video-oculography examination.
- •Oculomotor disorders such as "fixation disorders" or "ocular tracking disorders".
- •Cognitive disorders of the neurovisual type (visual agnosia, prosopagnosia, visuo-spatial disorder or visuo-perceptual disorder) or aphasia.
结局指标
主要结局
Facial emotion recognition (FER) performances (dynamic set)
时间窗: Baseline; Week 6; 1 month post intervention
Change from Baseline and Comparison of FER performance between AD-TAR group and AD-Cognitive Stimulation group. Evaluation criteria: Scores to the Amsterdam Dynamic Facial Expression Set (ADFES). FER was assessed using pictures from the Amsterdam Dynamic Facial Expression Set (ADFES/ Van Der Schalk J, Hawk ST, Fischer AH, Doosje B. Moving faces, looking places: validation of the Amsterdam Dynamic Facial Expression Set (ADFES). Emotion. 2011;11(4):907-20.), to test the recognition of the six facial basic emotions and neutral faces. There were four pictures per emotion, for a total of 28. For each picture, participants were asked to select one of the seven labels (anger, disgust, fear, sadness, happiness, surprise and neutral), with a maximum of 8 seconds of response time per picture.
Facial emotion recognition (FER) performances
时间窗: Baseline; Week 6; 1 month post intervention
Change from Baseline and Comparison of FER performance between AD-TAR group and AD-Cognitive Stimulation group. Evaluation criteria: Scores to Ekman Faces task (1976). FER was assessed using pictures from the Ekman Faces task (1976), to test the recognition of the six facial basic emotions and neutral faces. There were four pictures per emotion, for a total of 28. For each picture, participants were asked to select one of the seven labels (anger, disgust, fear, sadness, happiness, surprise and neutral), with a maximum of 8 seconds of response time per picture.
次要结局
- Eye movements behaviors during Facial emotion recognition (FER)(Baseline; Week 6; 1 month post intervention)
- Eye-Tracking Measurements during Facial emotion recognition (FER)(Baseline; Week 6; 1 month post intervention)
- Eye gaze strategies during Facial emotion recognition (FER) (dynamic set)(Baseline; Week 6; 1 month post intervention)
- The Family caregiver's burden(Baseline; Week 6; 1 month post intervention)
- Facial emotion recognition (FER) performances - Response times(Baseline; Week 6; 1 month post intervention)
- Facial emotion recognition (FER) performances - Response times (dynamic set)(Baseline; Week 6; 1 month post intervention)
- Behavioral disorders(Baseline; Week 6; 1 month post intervention)
- Global cognitive performance(Baseline; Week 6; 1 month post intervention)