Comparison of the effects of endurance and endurance-strength training on the endothelial dysfunction in women with abdominal obesity

Not Applicable

• Conditions: E66; Obesity

• Registration Number: DRKS00019832
• Lead Sponsor: The National Science Centre

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-12-19
• Study Start: 2020-02-26
• Results First Posted: 2021-04-12
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 101

Inclusion Criteria

Obesity (body mass index (BMI) = 30 kg/m2), waist circumference > 80 cm; percentage of body fat assessed by bioimpedance = 33% and stable body weight in the month prior to the trial (permissible deviation ± 1 kg).

Exclusion Criteria

Secondary form of obesity and/or secondary form of hypertension, type 2 diabetes mellitus, history of coronary artery disease, stroke (including transient ischaemic attack), congestive heart failure, clinically significant arrhythmias or conduction disorders, malignancy, history of use of any dietary supplements within 3 months before the study, poorly controlled hypertension (mean systolic blood pressure > 140 mmHg and/or mean diastolic blood pressure > 90 mmHg) during the month prior to the trial and/or necessity to modify antihypertensive treatment in the last 3 months, lipid disorders requiring the implementation of drug treatment in the last 3 months, abnormal liver, kidney, or thyroid gland function, clinically significant acute or chronic inflammatory process within the respiratory, digestive or genitourinary tract or in the oral cavity, pharynx or paranasal sinuses or connective tissue disease or arthritis, history of infection in the month, nicotine, alcohol or drug abuse, pregnancy or childbirth at enrolment or in the 3 months before enrolment, breast-feeding in the 3 months prior to enrolment, any other condition that would make participation not in the best interests of the subject, or could prevent, limit or confound the efficacy of the study.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in the following endothelial function parameters: asymmetric dimethylarginine (ADMA), endothelial nitric oxide synthase (eNOS), homocysteine (Hcy), nitrite (NO2), nitrate (NO3), plasminogen activator inhibitor type1 (PAI-1), vascular endothelial growth factor (VEGF).<br><br>All parameters were measured before and after 3-months of intervention.