Effect of single dose administration of trichlormethiazide on the serum level and clearance of uric acid: open-label controlled dose-escalating trial with healthy Japanese male volunteers

Not Applicable

• Conditions: hyperuricemia

• Registration Number: JPRN-UMIN000007013
• Lead Sponsor: Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-01-04
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: Male
• Target Recruitment: 8

Inclusion Criteria

Not provided

Exclusion Criteria

1. Disease that should be treated 2. On medical treatment 3. History of cardiovascular disease 4. Liver disease (AST >40 or ALT >40) 5. Kidney disease (serum creatinine >1.2 mg/dL) 6. Serum uric acid level >7.0 mg/dL 7. Serum electrolyte abnormality 8. Hematocrit >50% 9. Allergic reaction to thiazide and its related diuretics 10. Systolic blood pressure <90 mmHg or >140 mmHg 11. Body weight <40 kg or >90 kg 12. Not appropriate to this study by other reasons

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in the serum uric acid level and uric acid clearance by single dose administration of trichlormethiazide

Secondary Outcome Measures

Name	Time	Method
Relation between the polymorphisms of MRP4 and the serum uric acid level or uric acid clearance