ACTRN12624000534583已完成1 期
Effects of exogenous and endogenous glucose-dependent insulinotropic polypeptide on gastric emptying, blood pressure, splanchnic blood flow and glycaemia in healthy older subjects
niversity of Adelaide0 个研究点目标入组 18 人开始时间: 2024年4月30日最近更新:
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 18
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomised controlled trial
- 主要目的
- Treatment
- 盲法
- Blinded (masking used)
入排标准
- 年龄范围
- 65 Years 至 80 Years（—）
- 性别
- All
入选标准
- •Male or female healthy participants
- •Body Mass Index (BMI) 19 - 35 kg/m²
排除标准
- •Participants with diabetes, a history of severe respiratory, cardiovascular, hepatic and/or renal disease (severe in that the social or physical manifestation of the disease, or living with the condition, impact negatively and significantly on the individuals’ ability to lead a normal day to day life), chronic alcohol abuse or epilepsy (excluded by history) or if iron status, or liver function tests are outside the following ranges:
- •Alanine aminotransferase (ALT)0 - 55 U/L
- •Alkaline phosphatase30 - 110 U/L
- •Aspartate transaminase0 - 45 U/L
- •Amylase and/or lipase>3 x ULN
- •Bilirubin6 - 24 mmol/L
- •Ferritin15 – 200 ng/mL (Females)
- •30 – 300 ng/mL (Males)
- •Haemoglobin115 - 155 g/L (Females)
- •135 – 172 g/L (Males)
- •Participants with a creatinine clearance cut-off of < 50 ml/min
- •Calculated creatinine clearance will be determined as follows (29):
- •Cr clearance = [140 - age (years) x weight (kg)] / [0.814 x serum creatinine (µmol/L)]
- •(For female subjects, multiply Cr clearance x 0.85)
- •Participants requiring medication likely to influence BP or gastrointestinal function
- •Participants with a past history of gastrointestinal disease, including known gastroparesis, significant upper gastrointestinal symptoms and previous gastric surgery
- •Participants with a history of unexplained pancreatitis, chronic pancreatitis, pancreatectomy,
- •Participants with a current or prior history of c-cell carcinoma
- •Smoking > 10 cigarettes/day
- •Alcohol consumption > 20 g/day
- •Participants who have donated blood in the previous 12 weeks
研究者
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