Evaluation of Lung Deposition of Aerosol Via HFNC in Healthy Adults
试验速览
- 阶段
- 不适用
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- radioaerosol deposition index into the lungs
研究概览
简要总结
The aerosol associated with noninvasive ventilation (NIV) and high flow therapy with nasal interface have been employed in an attempt to relieve respiratory distress and optimize the deposition of drugs by inhalation.
Some studies report the effects of NIV association with fogging in healthy subjects, asthmatics and COPD 7.8, but studies evaluating the association between high flow nasal mist interface and therapy are scarce and most are found in vitro and animal models. The objective of this study is to evaluate the deposition of the aerosol scintigraphy using the high flow nasal interface system with vibrating mesh nebulizers using in healthy adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The study included healthy individuals of both sexes,
- •between 18 to 65 years,
- •without history of lung disease and forced vital capacity (FVC) or forced expiratory volume in the first second (FEV1) higher or equal to 80% from predicted values,
- •ability to verbal commands understand and
- •willing to provide signed consent to participate in this study.
排除标准
- •Participants were excluded if there unable to understand and follow the procedures and were pregnant and unable to tolerate nebulization.
结局指标
主要结局
radioaerosol deposition index into the lungs
时间窗: 1 month
次要结局
未报告次要终点
研究者
Daniella Cunha Brandao
Luciana Alcoforado Mendes da Silva
Universidade Federal de Pernambuco