To study the effects of Lamotrigine and Pregabalin in patients with pain after stroke and treatment of drug resistant cases either by repetitive transcranial magnetic stimulation (rTMS) or by placebo.
Phase 4
- Conditions
- Health Condition 1: null- Diagnosed case of post-stroke pain
- Registration Number
- CTRI/2012/02/002438
- Lead Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences SGPGIMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
1.Diagnosis of post-stroke pain
1.age of patient between 18-70 years.
3.Base line Pain at VAS >= 50mm on 100mm scale.
4.Informed signed consent
Exclusion Criteria
1.Peripheral neuropathy
2.Pericapsulitis
3.Dementia
4.Malignant disease
5.Recent MI
6.Liver/renal failure
7.Known allergy to lamotrigine or pregabalin
8.Pregnant or lactating
9.The patients with cardiac pacing or any metallic implantation will be excluded from rTMS.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.Efficacy of Lamotrigine and Pregabalin in the Treatment of central post-stroke pain at VAS scale. <br/ ><br>2.The efficacy of rTMS (repetitive magnetic stimulation) will be evaluated in the refractory patients. <br/ ><br>Timepoint: Completion of 12 weeks in each arm
- Secondary Outcome Measures
Name Time Method Side effect of each drugs <br/ ><br>Timepoint: 12 weeks