Comparative research on the effectiveness of dexmedetomidine and local anesthesia for surgically extracting mandibular third molars

Phase 2/3

Not yet recruiting

Conditions: Bilateral impacted tooth

Registration Number: CTRI/2023/06/054370

Lead Sponsor: Dr Heena Khan

Brief Summary: Pain is one of the most importantcomplications in the extraction of teeth which can even cause the patients not willing to seekfurther dental treatment. Becoming aware of the need for a surgery evokesfeelings of fear and anxiety in many patients. Dexmedetomidineis a selective alphaâ€‘2 adrenoceptor agonist. It is conventionally used as asedative in the intensive care unit.

However, recently, the application of dexmedetomidine as an adjuvantto a local anesthetic agent has been studied. The present study intends toevaluate the effectiveness of dexmedetomidine as an adjuvant to 2% lignocainewith adrenaline for surgical removal of impacted mandibular third molar.

A total of 15 patients who require surgical removal of impactedmandibular third molar extraction will be included in the study. Patients inthe study group will receive 2%

lignocaine and adrenaline with 1 mcg/ml dexmedetomidine. Patients inthe control group will receive 2% lignocaine with 1:200000 adrenaline. Theparameters for evaluation will be onset and duration of action, pulse rate,blood pressure, oxygen saturation, and blood loss along with patientsatisfaction score.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 15

Inclusion Criteria

1.ASA class I patient 2.Age group18-40 years 3.Bilateral similar impaction (with same classification and difficulty index).

Exclusion Criteria

1.Patients with a known history of an allergy or hypersensitivity to lignocaine or dexmedetomidine, 2.Pregnant or lactating mothers 3.Patients with acute pericoronitis.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Faster onset of local anaesthesia, prolonged duration of local anaesthesia, decrease in bleeding intraoperatively	One and half year

Secondary Outcome Measures

Name	Time	Method
Better hemodynamic stability	Two weeks
Faster action of onset	Once LA is injected (2-3 minutes)
Prolong duration of anaesthesia	Assessed from injecting LA to when the effect is weaned of (usually 2-3 hours)
Patient experience	Post operatively 1 - 2 hours
Decrease in bleeding	Assessed after surgical extraction immediately

Trial Locations

Locations (1): Yenepoya Dental College
🇮🇳
Kannada, KARNATAKA, India
Yenepoya Dental College
🇮🇳Kannada, KARNATAKA, India
Dr Heena Khan
Principal investigator
7303715994
drheenakhanx@gmail.com