Comparison of Two regimens of milrinone infusion in paediatric patients undergoing Tetralogy of fallot repair

Tetralogy of Fallot (TOF) is a complex congenital heart defect characterized by four key components: ventricular septal defect, pulmonary stenosis, right ventricular hypertrophy, and an overriding aorta. Postoperative management of these patients is critical and often requires careful titration of inotropic and vasodilatory support to optimize cardiac function and minimize morbidity. Milrinone, a phosphodiesterase III inhibitor, is commonly used in the perioperative period for patients undergoing cardiac surgery. It provides inotropic support and vasodilation, which can improve cardiac output and reduce pulmonary vascular resistance. However, the optimal dosing strategy for milrinone in pediatric patients undergoing TOF repair remains a topic of debate.

This study aims to compare two different milrinone infusion . By evaluating the hemodynamic effects, vasopressor and inotrope requirements, and postoperative outcomes, this study seeks to provide insights into the most effective and safe milrinone dosing strategy for this patient population.

The findings of this study will contribute to the development of evidence-based guidelines for the  patient outcomes and reducing mortality