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Lifestyle Control of Postprandial Hyperglycemia

Not Applicable
Completed
Conditions
Type 2 Diabetes
Interventions
Behavioral: Low-carbohydrate diet
Behavioral: High-carbohydrate diet
Behavioral: Low-carbohydrate diet with post-meal walking
Registration Number
NCT02683135
Lead Sponsor
University of British Columbia
Brief Summary

Large spikes in blood glucose experienced after meals in people with type 2 diabetes are known to damage blood vessels. Low carbohydrate high fat diets and exercise can improve blood glucose control in people with type 2 diabetes but it is unclear how these two strategies interact to affect blood vessel function and inflammation. We will examine how following a short-term low carbohydrate high fat diet (4 days) with or without post-meal walking impacts markers of blood vessel function and inflammation. We will also examine how a single low carbohydrate high fat meal, with or without post-meal walking, impacts blood glucose control and blood vessel function. Findings will help determine the best lifestyle approach for improving cardiovascular health in type 2 diabetes.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
16
Inclusion Criteria
  • Diagnosed with type 2 diabetes (at least 6 months ago)
  • Aged 40-75
  • Engaging in 2 or less moderate-to-vigorous exercise bouts per week in the last 3 months
  • Ability to understand and communicate in English to interact with the personal trainer
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Exclusion Criteria
  • Diagnosed coronary artery disease
  • Any contraindications to exercise (e.g., musculoskeletal injury)
  • Prior history of cardio- or cerebrovascular disease or myocardial infarction
  • Hypertension that is not controlled by medication (systolic blood pressure (BP) >160 mmHg and/or diastolic BP >99 mmHg)
  • Change in diabetes medications in the previous 6 months
  • Diagnosed with peripheral neuropathy
  • Taking exogenous insulin
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Study & Design

Study Type
INTERVENTIONAL
Study Design
CROSSOVER
Arm && Interventions
GroupInterventionDescription
Low-carbohydrate dietLow-carbohydrate diet-
Low-carbohydrate diet with post-meal walkingLow-carbohydrate diet with post-meal walking-
High-carbohydrate dietHigh-carbohydrate diet-
Low-carbohydrate diet with post-meal walkingLow-carbohydrate diet-
Primary Outcome Measures
NameTimeMethod
Difference in glycemic control assessed by continuous glucose monitoring in low-carbohydrate, low-carbohydrate plus post-meal walking, and high-carbohydrate low-fat arm.4-day average glucose levels assessed in each arm.
Secondary Outcome Measures
NameTimeMethod
Change from baseline in circulating inflammatory cytokines after 4 days of intervention.Fasting measurements taken on day 1 and day 5.
Change from baseline in toll-like receptors 2 and 4 expression on white blood cells after 4 days of intervention.Fasting measurements taken on day 1 and day 5.
Change from baseline in flow mediated dilation of brachial artery after 4 days of intervention.Fasting measurements taken on day 1 and day 5.

Trial Locations

Locations (1)

University of British Columbia, Okanagan.

🇨🇦

Kelowna, British Columbia, Canada

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