Lifestyle Control of Postprandial Hyperglycemia
- Conditions
- Type 2 Diabetes
- Interventions
- Behavioral: Low-carbohydrate dietBehavioral: High-carbohydrate dietBehavioral: Low-carbohydrate diet with post-meal walking
- Registration Number
- NCT02683135
- Lead Sponsor
- University of British Columbia
- Brief Summary
Large spikes in blood glucose experienced after meals in people with type 2 diabetes are known to damage blood vessels. Low carbohydrate high fat diets and exercise can improve blood glucose control in people with type 2 diabetes but it is unclear how these two strategies interact to affect blood vessel function and inflammation. We will examine how following a short-term low carbohydrate high fat diet (4 days) with or without post-meal walking impacts markers of blood vessel function and inflammation. We will also examine how a single low carbohydrate high fat meal, with or without post-meal walking, impacts blood glucose control and blood vessel function. Findings will help determine the best lifestyle approach for improving cardiovascular health in type 2 diabetes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
- Diagnosed with type 2 diabetes (at least 6 months ago)
- Aged 40-75
- Engaging in 2 or less moderate-to-vigorous exercise bouts per week in the last 3 months
- Ability to understand and communicate in English to interact with the personal trainer
- Diagnosed coronary artery disease
- Any contraindications to exercise (e.g., musculoskeletal injury)
- Prior history of cardio- or cerebrovascular disease or myocardial infarction
- Hypertension that is not controlled by medication (systolic blood pressure (BP) >160 mmHg and/or diastolic BP >99 mmHg)
- Change in diabetes medications in the previous 6 months
- Diagnosed with peripheral neuropathy
- Taking exogenous insulin
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Low-carbohydrate diet Low-carbohydrate diet - Low-carbohydrate diet with post-meal walking Low-carbohydrate diet with post-meal walking - High-carbohydrate diet High-carbohydrate diet - Low-carbohydrate diet with post-meal walking Low-carbohydrate diet -
- Primary Outcome Measures
Name Time Method Difference in glycemic control assessed by continuous glucose monitoring in low-carbohydrate, low-carbohydrate plus post-meal walking, and high-carbohydrate low-fat arm. 4-day average glucose levels assessed in each arm.
- Secondary Outcome Measures
Name Time Method Change from baseline in circulating inflammatory cytokines after 4 days of intervention. Fasting measurements taken on day 1 and day 5. Change from baseline in toll-like receptors 2 and 4 expression on white blood cells after 4 days of intervention. Fasting measurements taken on day 1 and day 5. Change from baseline in flow mediated dilation of brachial artery after 4 days of intervention. Fasting measurements taken on day 1 and day 5.
Trial Locations
- Locations (1)
University of British Columbia, Okanagan.
🇨🇦Kelowna, British Columbia, Canada