To study the oxidant-antioxidant status in vitiligo patients
- Conditions
- Health Condition 1: null- Vitiligo
- Registration Number
- CTRI/2013/01/003312
- Lead Sponsor
- Employees State Insurance Corporation Post Graduate Institute of Medical Sciences Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 150
1. Patients with vitiligo attending dermatology outpatient clinic
2. Age group 18-45 years (at the time of entry into study)
3. Constant dietary habits for the past 1 year
1. Cigarette smoking
2. Alcohol intake during past 3 months
3. Intake of folic acid, vitamin B6 and B12 during past 2 months
4. Intake of antioxidant supplements during past 3 months
5. Any systemic disease associated with altered serum Hcy levels. This will include known cases of cardiovascular disease, renal failure, diabetes mellitus, hypertension, hypothyroidism, hyperthyroidism & chronic liver disease and patients with any relevant findings on general and systemic examination.
6. Dermatological diseases known to affect serum Hcy levels, including psoriasis, Behcetâ??s disease, SLE.
7. Intake of any drugs known to affect Hcy levels, including methotrexate, INH, isotretinoin, cyclosporine, penicillamine, phenytoin, carbamazepine, OCPs, hydralazine, L-dopa, procarbazine, acetylcysteine, cholestyramine and cycloserine.
8. Pregnant females and females in 1-week postpartum period
9. Patients with any haematological or biochemical abnormality observed during routine laboratory investigations
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare levels of serum homocysteine and total antioxidant status of cases to those of controlsTimepoint: 10 months
- Secondary Outcome Measures
Name Time Method To correlate levels of serum homocysteine and serum antioxidant status in vitiligo patients with the activity of the diseaseTimepoint: 10 months